Results 101 to 110 of about 4,789,466 (273)

A Post-Authorisation Safety Study of a Respiratory Syncytial Virus Vaccine in Pregnant Women and Their Offspring in a Real-World Setting: Generic Protocol for a Target Trial Emulation

Vaccines
Background: Assessing the real-world safety of preventive products against respiratory syncytial virus (RSV) in pregnant women holds significant public health implications, especially as vaccination programs become more widespread.
Odette de Bruin, Linda Nab, Jungyeon Choi, Oisin Ryan, Hae-Won Uh, Fariba Ahmadizar, Shahar Shmuel, Heather Rubino, Kitty Bloemenkamp, Cynthia de Luise, Miriam Sturkenboom   +10 more
doaj   +1 more source

Establishment of a Responsive Tooth‐on‐a‐Chip Platform for the Assessment of Regenerative Factors in Dental Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Using a tooth‐on‐a‐chip model that recreates interactions between dental epithelial and mesenchymal cells, the authors show that sequential FGF10+BMP4, BMP2, and Emdogain produce distinct, biologically consistent regenerative responses. The platform recapitulates known signal‐specific effects and, for the first time, reveals an influence of Emdogain on
Chong Huang, Wei Ji, Fang Yang, X. Frank Walboomers   +3 more
wiley   +1 more source

Evaluating bias in target trial emulation for heart failure across statistical and deep learning methods

Nature Communications
Target trial emulation (TTE) is increasingly used for causal inference from observational data, but remains vulnerable to confounding by indication, and whether advanced adjustment methods mitigate this bias is unclear.
Zhengxian Fan, Qianqian Yang, Yifan Hu, Goodarz Danaei, George Davey Smith, Shishir Rao, Kazem Rahimi   +6 more
doaj   +1 more source

Effect of Early Versus Delayed Tracheostomy Strategy on Functional Outcome of Patients With Severe Traumatic Brain Injury: A Target Trial Emulation

Critical Care Explorations
OBJECTIVES:. Optimal timing of tracheostomy in severe traumatic brain injury (TBI) is unknown due to lack of clinical trials. We emulated a target trial to estimate the effect of early vs.
Vassilis G. Giannakoulis, MD, Georgios Psychogios, MD, PhD, Christina Routsi, MD, PhD, Ioanna Dimopoulou, MD, PhD, Ilias I. Siempos, MD, DSc   +4 more
doaj   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Psoriasis Patients and Comorbid Type 2 Diabetes: A Population-based Target Trial Emulation

Supplemental data for the manuscript "Efficacy and Safety of Sodium-Glucose Cotransporter-2 Inhibitors in Psoriasis Patients and Comorbid Type 2 Diabetes: A Population-based Target Trial ...
Ji, Helen
core   +1 more source

Neuromorphic Electronics for Intelligence Everywhere: Emerging Devices, Flexible Platforms, and Scalable System Architectures

Advanced Materials, EarlyView.
The perspective presents an integrated view of neuromorphic technologies, from device physics to real‐time applicability, while highlighting the necessity of full‐stack co‐optimization. By outlining practical hardware‐level strategies to exploit device behavior and mitigate non‐idealities, it shows pathways for building efficient, scalable, and ...
Kapil Bhardwaj, Roshni Satheesh Babu, Yuxin Xia, Eva Bestelink, Radu Sporea, Nikos Hastas, Ioannis Zeimpekis, Dimitra G. Georgiadou, Sayani Majumdar   +8 more
wiley   +1 more source

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

Advanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab, Jack F. Murphy, Michael Bartolf‐Kopp, Jenny C‐C Hsin, Alice Chernaik, Frank McCaughan, Yan Yan Shery Huang, Tomasz Jungst, Jürgen Groll   +8 more
wiley   +1 more source

Emulation of Target Trials to Study the Effectiveness and Safety of Medical Interventions [PDF]

, 2016
Ideally, clinical guidelines would be informed by well-designed randomized experiments. However, it is generally not possible to conduct a randomized trial for every clinically relevant decision.
Huitfeldt, Anders
core   +2 more sources

Effects of Per- and Polyfluoroalkyl Substances (PFAS) Exposure Reduction on Serum Lipids in the Copenhagen City Heart Study: A Protocol for an Observational Cohort Study Emulating a Target Trial

Toxics
Per- and polyfluoroalkyl substances (PFAS) are environmental contaminants associated with higher serum lipids, although primarily in cross-sectional studies, limiting causal inference.
Georges Khoury, Laura Deen, Lars Christian Lund, Erich Batzella, Michelle C. Turner, Gorm Boje Jensen, Tina Kold Jensen, Sandra Søgaard Tøttenborg   +7 more
doaj   +1 more source