Results 81 to 90 of about 4,789,466 (273)

Sub‐1 ms Optoelectronic Synapse Based on {ZnCdO/ZnO} Multilayer Structure for High‐Speed Neuromorphic Vision Systems

Advanced Functional Materials, EarlyView.
Eu‐doped {ZnCdO/ZnO} structures grown on Si are developed, showcasing dual‐functionality controlled by europium doping. While high europium concentration transforms the device into an ultrafast, self‐powered photodetector, low‐doped structures can be used as an optoelectronic synapse.
Igor Perlikowski, Eunika Zielony, Adrian Kaim, Ewa Przeździecka   +3 more
wiley   +1 more source

Investigating the use of Target Trial Emulation in Neurological Disorders

The target trial emulation (TTE) framework was developed by Hernán and Robins to provide a structured methodology for using observational data to emulate a randomized controlled trial (RCT).
Simran Saggu, Kealey Nguyen, Marzieh Mussavi Rizi, Andrea Schneider, Abel Torres Espin, Rahul Kartik Desai, Thomas Van Essen   +6 more
core   +2 more sources

Synthetic target trial emulation and predictive modeling of amylin-pathway therapies for obesity and type 2 diabetes

Metabolism Open
Introduction: Amylin-pathway therapies represent a novel therapeutic class for obesity and type 2 diabetes, however head-to-head comparative data and long-term outcome predictions remain limited.
Faisal A. Al-Harbi, Ahmed K. Alsaif, Atheer G. Almutairi, Hussam J. Alshehri, Elan A. Aleidan, Ghaida S. Alabdulaaly, Mashael E. Alanazi, Ahmed Y. Azzam   +7 more
doaj   +1 more source

Practical elements to consider when emulating a target trial

Journal of Clinical Epidemiology
Target trial emulation, i.e., the analysis of observational data by explicitly emulating the design components of a randomized controlled trial (RCT), has gained attention in recent years as an approach to estimate causal effects of pharmacological or nonpharmacological interventions that are, on average, similar to those of RCTs.This article addresses
Tran, Viet-Thi, Porcher, Raphaël, Perrodeau, Elodie, Yaacoub, Sally, Boutron, Isabelle, Ravaud, Philippe   +5 more
openaire   +3 more sources

Analog Classification of Human Hand Gestures Exploiting Dendritic Integration With an Organic Artificial Soma

Advanced Functional Materials, EarlyView.
An organic neuromorphic architecture for the classification of human motor behavior is presented and validated. It performs somatic integration by linearly combining the activity from three muscles. An investigation of synaptic weights is presented and discussed in relationship with the classification performance.
Ilenia Sergi, Federico Rondelli, Francesco Torricelli, Federica Velluto, Anna De Salvo, Michele Di Lauro, Luciano Fadiga, Fabio Biscarini   +7 more
wiley   +1 more source

Reference Trial Emulation to Improve the Validity of Non-Interventional Comparative Effectiveness Research

In this commentary we discuss use of the “reference trial emulation” approach in non-interventional comparative effectiveness research, in which an existing randomized controlled trial (RCT) is used as a reference standard to both inform the design of a ...
Kevin Wing, Anna Schultze
core   +1 more source

Current practices in studies applying the target trial emulation framework: a protocol for a systematic review [PDF]

Introduction Observational studies represent an alternative to estimate real-world causal effects in the absence of available randomised controlled trials (RCTs).
Wason JMS, Bigirumurame T, Teare MD, Bryant A, Breckons M, Hiu SKW   +5 more
core   +3 more sources

Emulation of a Target Trial of Antihypertensive Medications on Weight Change

Journal of General Internal Medicine
Abstract Background Weight gain after starting antihypertensive medications is a frequent concern for patients, but there is limited data on expected weight change after initiation of these medications. A comparative effectiveness trial to evaluate this outcome would not be feasible.
Pi-I D. Lin, Sheryl L. Rifas-Shiman, Joshua Petimar, Han Yu, Matthew F. Daley, David M. Janicke, William J. Heerman, L. Charles Bailey, Carlos Maeztu, Kristina H. Lewis, Jessica G. Young, Jason P. Block   +11 more
openaire   +3 more sources

Neuromorphic Devices for Extreme Environments: State‐Variable Reliability and Stabilization Strategies

Advanced Functional Materials, EarlyView.
Neuromorphic devices for extreme environments are interpreted through the physical states that store and process information. Radiation, temperature extremes, and vacuum can perturb vacancies, filaments, trapped charges, polarization, interfaces, and readout signals.
Taehyun Park, Geon Park, Junhyung Cho, Jaechan Song, Wangmyung Choi, Jaehyun Hur, Nicola Gasparini, Hocheon Yoo   +7 more
wiley   +1 more source

Partitioning Time in Target Trial Emulation

In target trial emulation, the treatment strategies that patients follow are inferred from the treatments they actually receive in routine care. However, in most settings, the outcome may preclude the observation of planned treatment, giving rise to immortal time bias through misclassification of treatment strategy, while markers of treatment response ...
Zoumenou, Harold Tankpinou, Ferreira, Simon, Assaad, Charles, Hajage, David, Carrat, Fabrice, Beurton, Alexandra, Lapidus, Nathanaël, Bystrova, Daria, Glemain, Benjamin   +8 more
openaire   +2 more sources