Results 41 to 50 of about 4,789,466 (273)

[Designing observational studies by target trial emulation]. [PDF]

Nederlands tijdschrift voor geneeskunde, 2023
Ideally, causal research questions will be answered with randomized trials, but this is not always feasible for practical, ethical, or methodological reasons. To obtain a reliable answer to causal questions with observational data, target trial emulation has been introduced, in which an observational study is designed, conducted, and analyzed emulating
Gelder, M.M.H.J. van, Rodwell, L., Roes, K.C.B.   +2 more
openaire   +3 more sources

An operational target trial emulation framework for causal inference using electronic health record data

npj Digital Medicine
Target trial emulation (TTE) enables causal inference from electronic health record (EHR) data when randomized clinical trials are infeasible, but its validity depends on whether EHR data can support the required trial design components.
Yanfei Wang, Yongqiu Li, Tuo Lin, Yi Guo
doaj   +1 more source

Oral glucocorticoids added to ILD‐modifying therapy in systemic sclerosis‐associated interstitial lung disease: a target trial emulation study from the EUSTAR database.

Arthritis Care &Research, Accepted Article.
Objectives We aimed to estimate whether adding oral glucocorticoids to ILD‐modifying therapy improves 12‐month lung outcomes in systemic sclerosis‐associated interstitial lung disease (SSc‐ILD). Methods We emulated a target trial using the EUSTAR database.
Zubeyir Salis, Simona Truglia, Oliver Distler, Gábor Kumánovics, Gianluca Moroncini, David Launay, Silvia Bellando‐Randone, Gonçalo Boleto, Nicoletta Del Papa, Ana Maria Gheorghiu, Duygu Temiz Karadag, Zguro Batalov, Gabriella Szucs, Michele Iudici, The EUSTAR collaborators   +14 more
wiley   +1 more source

The Role of Ultra‐Thin Passive Films and Organic Adsorbates on Aluminum Chips for a Friction‐Induced Solid‐State Recycling Process

Advanced Engineering Materials, EarlyView.
Despite benefits to storage stability and handleability of aluminum scrap, octadecyl phosphonic acid (ODPA) SAMs reduce the tensile strength of wires produced using friction‐induced recycling. Etching and methyl diphosphonic acid (MDPA) coatings, however, have little effect.
Timothy D. Goller, Steffen Gabsa, Werner Homberg, Guido Grundmeier   +3 more
wiley   +1 more source

Comparative Effectiveness of Inhaled Epoprostenol and Nitric Oxide in Acute Hypoxemic Respiratory Failure: A Target Trial Emulation

, 2022
Study protocol for a Multicenter retrospective two step observational study: (1) practice patterns of epoprostenol and inhaled nitric oxide and (2) cluster randomized target trial emulation comparative effectiveness study for refractory hypoxemia among ...
Nicholas Bosch
core   +1 more source

Intermediate Resistive State in Wafer‐Scale Vertical MoS2 Memristors Through Lateral Silver Filament Growth for Artificial Synapse Applications

Advanced Functional Materials, EarlyView.
In MOCVD MoS2 memristors, a current compliance‐regulated Ag filament mechanism is revealed. The filament ruptures spontaneously during volatile switching, while subsequent growth proceeds vertically through the MoS2 layers and then laterally along the van der Waals gaps during nonvolatile switching.
Yuan Fa, Milan Buttberg, Ke Ran, Rana Walied Ahmad, Dennis Braun, Lukas Völkel, Jimin Lee, Sofía Cruces, Bart Macco, Bárbara Canto, Holger Lerch, Thorsten Wahlbrink, Holger Kalisch, Michael Heuken, Andrei Vescan, Joachim Mayer, Zhenxing Wang, Ilia Valov, Stephan Menzel, Max C. Lemme   +19 more
wiley   +1 more source

Mapping eligibility criteria in oncology target trial emulations using real-world data: a scoping review

BMC Medical Research Methodology
Background Target trial emulations often face challenges in accurately identifying the intended target population within real-world data (RWD) because eligibility criteria cannot always be directly mapped to available variables. This scoping review aimed
Rou-Zhen Chen, Sweta Balaji, Selen Bozkurt, Joshua D. Wallach, Ravi B. Parikh   +4 more
doaj   +1 more source

Wearable Smart Patches on Sustainable Chitosan With Reversible Microbial Growth‐Inhibitory Properties

Advanced Functional Materials, EarlyView.
ABSTRACT Chitosan, a polysaccharide upcycled from biowaste, has long promised sustainable, biocompatible, and antimicrobial films and devices, an appeal reinforced by its recent regulatory recognition, with several chitosan‐based antibacterial dressings gaining clearance through the Food and Drug Administration's 510(k) pathway.
Jacopo Nicoletti, Kubra Kocak, Andrea Michel, Enrico Cavarzerani, Ali Raza, Petr Rohzin, Nouha Loudhaief, Saimir Frroku, Nicolò Baldovin, Hazrat Bilal, Alvise Perosa, Maurizio Selva, Flavio Rizzolio, Luca Sbuelz, Sabrina Tamburini, Domenico De Fazio, Giovanni Antonio Salvatore   +16 more
wiley   +1 more source

Introduction and application of an auxiliary implementation tool (CERBOT) for target trial emulation study [PDF]

The rapid advancement of causal inference is driving a paradigm shift across various disciplines. "Target trial emulation" has emerged as an exceptionally promising framework for observational real-world studies, attracting substantial attention from ...
Ke, Lixin, Lu, Cuncun, Chen, Zijia, Wang, Zhifei, Wang, Ziyi   +4 more
core   +1 more source

Causal predictive inference and target trial emulation

, 2022
Causal inference from observational data can be viewed as a missing data problem arising from a hypothetical population-scale randomized trial matched to the observational study. This links a target trial protocol with a corresponding generative predictive model for inference, providing a complete framework for transparent communication of causal ...
Yiu, Andrew, Fong, Edwin, Walker, Stephen, Holmes, Chris   +3 more
openaire   +2 more sources