Results 31 to 40 of about 4,789,466 (273)

Effects of azithromycin in young adults with cystic fibrosis: a protocol for emulating a published randomised controlled trial using registry data

BMJ Open
Introduction Target trial emulation is a framework for evaluating the effects of treatments using observational data. The trial emulation approach involves specifying key elements of a protocol for a target trial (a randomised controlled trial designed ...
, Bin Huang, Rhonda Szczesniak, Lutz Naehrlich, Freddy Frost, Gwyneth Davies, Sanja Stanojevic, Susan Charman, Nicole Mayer-Hamblett, Emily Granger, Alex Gifford, Josh Ostrenga, Jonathan Todd, Susan Christine Charman, Elizabeth Cromwell, Nicole Mayer Hamblett, Ruth Keogh, Josh Osttrenga   +17 more
doaj   +1 more source

Effectiveness of total hip arthroplasty versus non-surgery on patient-reported hip function at 3 months: a target trial emulation study of patients with osteoarthritis

Acta Orthopaedica
Background and purpose: This study introduces an innovative research design in the field of orthopedics, using a target trial emulation approach. We aimed to assess the causal effects of total hip arthroplasty (THA) compared with nonoperative treatment ...
Amanda D Klaassen, Wiard Jorritsma, Nienke W Willigenburg, Carina L E Gerritsma, Bas L E F Ten Have, Dirk Jan F Moojen, Maaike G J Gademan, Rolf H H Groenwold, Rudolf W Poolman   +8 more
doaj   +1 more source

Transparent Reporting of Observational Studies Emulating a Target Trial—The TARGET Statement [PDF]

JAMA
Importance When randomized trials are unavailable or not feasible, observational studies can be used to answer causal questions about the comparative effects of interventions by attempting to emulate a hypothetical pragmatic randomized trial (target trial). Published guidance to aid reporting of these studies is
Cashin, Aidan G, Hansford, Harrison J, Hernán, Miguel A, Swanson, Sonja A, Lee, Hopin, Jones, Matthew D, Dahabreh, Issa J, Dickerman, Barbra A, Egger, Matthias, Garcia-Albeniz, Xabier, Golub, Robert M, Islam, Nazrul, Lodi, Sara, Moreno-Betancur, Margarita, Pearson, Sallie-Anne, Schneeweiss, Sebastian, Sharp, Melissa K, Sterne, Jonathan A C, Stuart, Elizabeth A, McAuley, James H   +19 more
openaire   +5 more sources

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

Why is target trial emulation not being used in health technology assessment real-world data submissions?

Journal of Comparative Effectiveness Research
Alejandra Castanon, Stephen Duffield, Sreeram Ramagopalan, Robert Reynolds   +3 more
doaj   +2 more sources

Raising the bar for causal inference: PLOS Medicine adopts the TARGET guidelines for target trial emulation studies.

PLoS Medicine
The TARGET guidelines aim to improve transparency and consistency in reporting of observational studies that emulate target trials. In alignment with these goals, PLOS Medicine fully endorses the TARGET guidelines and now asks that new submissions of ...
Helen Lumbard, PLOS Medicine Staff Editors   +1 more
doaj   +1 more source

Estimating the Effect of Adhering to the Recommendations of the 2019 Canada’s Food Guide on Health Outcomes in Older Adults: Protocol for a Target Trial Emulation

JMIR Research Protocols
BackgroundThe 2019 Canada’s Food Guide provides universal recommendations to individuals aged ≥2 years. However, the extent to which these recommendations are appropriate for older adults is unknown.
Didier Brassard, Nancy Presse, Stéphanie Chevalier   +2 more
doaj   +1 more source

Deep Learning Pose Estimation for Phenotyping of Co‐Occurring Hyperkinetic Movement Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore whether routine outpatient video combined with deep learning‐based pose estimation and clinically interpretable kinematic features can support multi‐label phenotyping of co‐occurring hyperkinetic movement disorders (HMDs).
Laura Cif, Diane Demailly, Gabriella A. Horvàth, Juan Dario Ortigoza Escobar, Nathalie Dorison, Mayté Castro Jiménez, Cécile A. Hubsch, Thomas Wirth, Gun‐Marie Hariz, Sophie Huby, Morgan Dornadic, Zohra Souei, Muhammad Mushhood Ur Rehman, Simone Hemm, Mehdi Boulaymen, Eduardo M. Moraud, Jocelyne Bloch, Xavier Vasques   +17 more
wiley   +1 more source

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Engagement Patterns With an Artificial Intelligence Health Coach for Systemic Sclerosis Self‐Management: A Mixed Methods Study

Arthritis Care &Research, EarlyView.
Objective To evaluate utility of an artificial intelligence (AI) health coach for systemic sclerosis (SSc) self‐management and identify patterns associated with participant engagement. Methods We conducted a mixed methods study in which an AI health coach, powered by a large language model (LLM), was used to support self‐management for SSc.
Nirali Shah, Melanie Morris, Cristina Daraban, Sophia Johnson, Susan L. Murphy   +4 more
wiley   +1 more source