Results 11 to 20 of about 4,789,466 (273)

Conducting observational analyses with the target trial emulation approach: a methodological systematic review

BMJ Open
Objectives Target trial emulation is an approach that is increasingly used to improve transparency in observational studies and help mitigate biases. For studies declaring that they emulated a target trial, we aimed to evaluate the specification of the ...
Agnes Dechartres, Florence Tubach, Maxime Beydon, David Hajage, Noémie Simon-Tillaux, Guillaume L Martin, Carole Scheifer   +6 more
doaj   +2 more sources

Current practices in studies applying the target trial emulation framework: a protocol for a systematic review

BMJ Open, 2023
Introduction Observational studies represent an alternative to estimate real-world causal effects in the absence of available randomised controlled trials (RCTs).
Andrew Bryant, M Dawn Teare, Matthew Breckons, James M S Wason, Theophile Bigirumurame, Shaun Kuan Wei Hiu   +5 more
doaj   +2 more sources

Importance of cohort and target trial emulation in clinical research

Cell Reports Medicine
Advances in cohort studies and target trial emulation provide substantial evidence for policymaking to enhance global health. Moving forward, key priorities should focus on standardizing data processing protocols, advancing life-course research ...
Xiaohua Liang, Di Zhang, Huan Wang, Muhammad Fahad Tahir, Lanling Chen, Xiaodong Zhao, Zhiyong Zou   +6 more
doaj   +3 more sources

Introduction to target trial emulation in rehabilitation: a systematic approach to emulate a randomized controlled trial using observational data [PDF]

European Journal of Physical and Rehabilitation Medicine
Rehabilitation providers and policymakers need valid evidence to make informed decisions about the healthcare needs of the population. Whenever possible, these decisions should be informed by randomized controlled trials (RCTs). However, there are circumstances when evidence needs to be generated rapidly, or when RCTs are not ethical or feasible. These
Côté, Pierre, Negrini, Stefano, Donzelli, Sabrina, Kiekens, Carlotte, Arienti, Chiara, Ceravolo, Maria G, Gross, Douglas P, Battel, Irene, Ferriero, Giorgio, Lazzarini, Stefano G, Dan, Bernard, Shearer, Heather M, Wong, Jessica J, Colvin, Christopher, Cordani, Claudio, Cusick, Anne, Del Furia, Matteo, Every-Palmer, Susanna, Feys, Peter, Gutenbrunner, Christoph, Juhl, Carsten B, Levack, William MM, Machalicek, Wendy, Martin, Rachelle, Merlo, Federico, Meyer-Feil, Thorsten, Miranda, Luca, Mosconi, Bianca, Nudo, Randolph, Oral, Aydan, Røe, Cecilie   +30 more
core   +12 more sources

Anforderung an die Daten für die Target-Trial-Emulation: Eine Diskussion unter Betrachtung von Patientenregistern

GMS Medizinische Informatik, Biometrie und Epidemiologie
The article first considers basic requirements (e.g. recording of relevant confounders) and frequent sources of bias (e.g. immortal time bias) when using registry and other real-world data as the basis for comparative effectiveness analyses of treatments.
Mathes, Tim
doaj   +2 more sources

Analysing electronic health records:The benefits of target trial emulation [PDF]

, 2021
Aim: Electronic health records (EHRs) are increasingly used in effectiveness and safety research. However, these studies are often at risk of bias. This study demonstrates the relevance, and discusses challenges, of using target trial emulation to avoid ...
O'Kane, Maurice J., Bakker, Lytske J., Redekop, William K., Goossens, Lucas M.A.; id_orcid, Uyl-de Groot, Carin A., Lucas M.A. Goossens, Maurice J. O'Kane, William K. Redekop, Lytske J. Bakker, Carin A. Uyl-de Groot   +9 more
core   +1 more source

Target trial emulation studies in oncology: a comprehensive analysis. [PDF]

Oncologist
Abstract Background Target trial emulation (TTE) has emerged as an important framework for generating comparative effectiveness real-world evidence. However, the methodological characteristics and clinical utility of this framework within oncology remained insufficiently analyzed.
Tan C, Dai Z, Zhao R, Li K, Zhang B, Wang Y, Zhang Y, Liu L, Li N.   +8 more
europepmc   +3 more sources

Comparing Effect Estimates in Randomized Trials and Observational Studies From the Same Population: An Application to Percutaneous Coronary Intervention

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background To understand when results from observational studies and randomized trials are comparable, we performed an observational emulation of a target trial designed to ask similar questions as the VALIDATE (Bivalirudin Versus Heparin in ST‐Segment ...
Anthony A. Matthews, Karolina Szummer, Issa J. Dahabreh, Bertil Lindahl, David Erlinge, Maria Feychting, Tomas Jernberg, Anita Berglund, Miguel A. Hernán   +8 more
doaj   +1 more source

Target Trial Emulation

The Journal of Clinical Psychiatry
Target trial emulation (TTE) is an observational, quasi-experimental research design that emulates a randomized clinical trial (RCT) structure within a large set of observational data; the "target trial" is a hypothetical RCT that would have ideally answered the research question. TTEs can address study objectives that, for ethical or logistic reasons,
RH Groenwold, EL Fu
  +8 more sources

Target trial emulation.

, 2023
Target trial emulation.
Susan P. Walker (7464881), John McBain (13493254), Franca Agresta (14498088), Anthea C. Lindquist (7464884), Vivien MacLachlan (14498085), Susan P. Baohm (14498091), David Wilkinson (155514), Jon L. Quach (14498079), Richard J. Hiscock (7464866), Catharyn J. Stern (14498073), Stephen Tong (310909), Jeanie L. Y. Cheong (14498076), Lyle C. Gurrin (14498082), Amber L. Kennedy (7464875), Beverley J. Vollenhoven (14498070), Roxanne Hastie (4871989)   +15 more
core   +1 more source