Results 21 to 30 of about 4,789,466 (273)

Implementation of the trial emulation approach in medical research: a scoping review

BMC Medical Research Methodology, 2023
Background When conducting randomised controlled trials is impractical, an alternative is to carry out an observational study. However, making valid causal inferences from observational data is challenging because of the risk of several statistical ...
Giulio Scola, Anca Chis Ster, Daniel Bean, Nilesh Pareek, Richard Emsley, Sabine Landau   +5 more
doaj   +1 more source

Specification and emulation of a target trial of mode of delivery childhood health outcomes.

, 2022
Specification and emulation of a target trial of mode of delivery childhood health outcomes.
Arnon Wiznitzer (811594), Shiri Barbash-Hazan (13977940), Chen Yanover (361371), Smadar Shilo (10993386), Avi Ben-Haroush (322306), Irena Girshovitz (11451150), Eran Segal (26774), Pinchas Akiva (159427), Eran Hadar (5482964), Ayya Keshet (13977934), Hagai Rossman (13977937), Guy Amit (3978614), Maytal Bivas-Benita (210974)   +12 more
core   +1 more source

Target Trial Emulation: A Design Tool for Cancer Clinical Trials

JCO Clinical Cancer Informatics, 2023
PURPOSE To apply target trial emulation to explore the potential impact of eligibility criteria on the primary outcome of a randomized controlled trial. METHODS Simulations of a real-world explanatory trial of transarterial radioembolization for advanced unresectable hepatocellular carcinoma with portal vein invasion were performed to examine the ...
Sandi A. Kwee, Linda L. Wong, Christina Ludema, Chris K. Deng, Deborah Taira, Todd Seto, Douglas Landsittel   +6 more
openaire   +2 more sources

How work hours affect well-being: A target trial emulation [PDF]

PLoS ONE
Ballerina X. S. Chong, Chris G. Sibley, Joseph A. Bulbulia   +2 more
doaj   +2 more sources

Selective serotonin reuptake inhibitors (SSRIs) and osteoporosis: A target trial emulation using real-world data

, 2023
A target trial emulation using real-world data to study the impact of the selective serotonin reuptake inhibitors (SSRIs) sertraline, citalopram and escitalopram on the risk of ...
Michael Berk, Christopher Rohde, Lana Williams, Søren Dinesen Østergaard   +3 more
core   +1 more source

Die „Target Trial Emulation“ zu CAR-T im AMNOG

Monitor Versorgungsforschung, 2023
Das Konzept „Target Trial Emulation“ sowie propensity score-basierte Adjustierungsverfahren sind empfohlene Methoden, um in indirekten Vergleichen ohne Brückenkomparator systematische Verzerrung zu minimieren. Anhand des Vergleichs der einarmigen Evidenz
Janine Jakobs BS, Ronja Kerßenboom BS, Christina Schulat, Jörn Sindern   +3 more
doaj   +1 more source

The implementation of target trial emulation for causal inference: a scoping review protocol

, 2022
Target trial emulation (TTE) is one method to obtain causal evidence by emulating randomized trials using observational data. To our knowledge, even though a few review papers have focused on TTE usage within specific research fields, there has been no ...
Lin Yu, Hanxiao Zuo, Yan Yuan, Sandra Melody Campbell   +3 more
core   +1 more source

A protocol for emulating a published randomised controlled trial using registry data: effects of azithromycin in young adults with cystic fibrosis [PDF]

, 2023
Target trial emulation can be used to evaluate the effects of treatments using observational data. The trial emulation approach involves specifying key elements of a protocol for a target trial (a randomised controlled trial designed to address the ...
Todd, Jonathan, Frost, Freddy, Ostrenga, Josh, Keogh, Ruth, Cromwell, Elizabeth, Huang, Bin, Szczesniak, Rhonda, Mayer-Hamblett, Nicole, Granger, Emily, Charman, Susan, CF-Trial Emulation Network, Palipana, Anushka, Davies, Gwyneth, Gifford, Alex   +13 more
core   +1 more source

Effectiveness of Specific Health Check-ups in Japan for the primary prevention of obesity-related diseases: a protocol for a target trial emulation

BMJ Open, 2023
Introduction Concerns about public health threats have shifted towards obesity-related, non-communicable diseases in both developed and developing countries.
Tomohiro Shinozaki, Koji Kawakami, Masato Takeuchi   +2 more
doaj   +1 more source

Lithium for the prevention of suicide in US veterans: a target trial emulation. [PDF]

BMJ Ment Health
Background Lithium has long been considered to reduce suicidal behaviour in patients with affective disorders, but evidence from large real-world populations remains limited. Objective To estimate the effects of lithium initiation and ...
Szmulewicz AG, Gerlovin H, Rezaee N, Robb W, Martínez-Alés G, Liu H, Bossarte RM, Smith EG, Katz I, Ferguson R, Kessler RC, Hernan MA.   +11 more
europepmc   +3 more sources