Results 1 to 10 of about 4,789,466 (273)

Application of the target trial emulation framework to external comparator studies

Frontiers in Drug Safety and Regulation
External comparator (EC) studies are increasingly being used to generate evidence that supports the evaluation of emerging pharmacological treatments for regulatory and health technology assessment (HTA) purposes.
Kellyn Arnold, Luis Antunes, Briana Coles, Hopin Lee   +3 more
doaj   +6 more sources

Target Trial Emulation Using Hospital-Based Observational Data: Demonstration and Application in COVID-19

Life, 2023
Methodological biases are common in observational studies evaluating treatment effectiveness. The objective of this study is to emulate a target trial in a competing risks setting using hospital-based observational data. We extend established methodology
Oksana Martinuka, Maja von Cube, Derek Hazard, Hamid Reza Marateb, Marjan Mansourian, Ramin Sami, Mohammad Reza Hajian, Sara Ebrahimi, Martin Wolkewitz   +8 more
doaj   +3 more sources

Strengthening health technology assessment for cancer treatments in Europe by integrating causal inference and target trial emulation

The Lancet Regional Health. Europe
Summary: Health Technology Assessment (HTA) for reimbursement of all new cancer drugs in the European Union (EU) will be evaluated for all member states by a central European HTA starting in 2025.
Heiner C. Bucher, Frédérique Chammartin   +1 more
doaj   +3 more sources

Arthroplasty versus internal fixation for displaced femoral neck fractures in older patients with dementia: a target trial emulation study [PDF]

Acta Orthopaedica
Background and purpose: Target trial emulation can improve design transparency in observational comparative-effectiveness studies. We applied the framework to compare the outcome after arthroplasty with that of internal fixation (IF) in patients with ...
Simon Storgaard Jensen, Per Hviid Gundtoft, Rob G H H Nelissen, Jan-Erik Gjertsen, Alma B Pedersen   +4 more
doaj   +2 more sources

A comprehensive step-by-step approach for the implementation of target trial emulation: Evaluating fluid resuscitation strategies in post-laparoscopic septic shock as an example

Laparoscopic, Endoscopic and Robotic Surgery
Objective: To develop and demonstrate a comprehensive methodological framework for target trial emulation (TTE) implementation via post-laparoscopic septic shock fluid management as a clinical case study.
Jie Yang, Lihui Wang, Lin Chen, Pengmin Zhou, Suibi Yang, Hongjie Shen, Lifeng Xing, Pengpeng Chen, Yuetian Yu, Hongying Ni, Zhongheng Zhang   +10 more
doaj   +3 more sources

Study protocol for a target trial emulation: CHoosing the right diAlysis Modality in clinical PractIce: hemOdiafiltratioN or hemodialysis (CHAMPION) [PDF]

BMC Nephrology
Background Randomized studies have demonstrated that high-volume hemodiafiltration results in reduced mortality compared to conventional hemodialysis treatment.
Sanne Roos, John Larkin, Linda H. Ficociello, Len A. Usvyat, Yue Jiao, Luca Neri, Vivi Zhou, Menno Brandjes, Peter J. Blankestijn, Michiel L. Bots, Saskia Haitjema, Marianne C. Verhaar, Roemer J. Janse, Robin W. M. Vernooij   +13 more
doaj   +2 more sources

When does IAPA begin? Interpreting corticosteroid dose thresholds in a target trial emulation [PDF]

Annals of Intensive Care
Dilek Kuzukıran Kocataş
doaj   +2 more sources

External comparator studies and the joint application of the estimand and target trial emulation frameworks

Frontiers in Drug Safety and Regulation
The estimand framework (EF) and the target trial emulation framework (TTEF) are two important frameworks that can inform the design and analysis of external comparator (EC) studies.
Gerd Rippin, Héctor Sanz
doaj   +3 more sources

Target trial emulation of survival outcomes for clinically localized prostate cancer treatments [PDF]

Discover Oncology
Background The ProtecT randomized trial found similar survival between active surveillance (AS), radiotherapy (RT), and radical prostatectomy (PT) in localized prostate cancer (PC), but observational studies yielded conflicting results.
Min Ho An, Chungsoo Kim, Kyungchan Min, Kyu-Ho Yi, Rae Woong Park, Minji Jung   +5 more
doaj   +2 more sources

Author's reply: When does IAPA begin? Interpreting corticosteroid dose thresholds in a target trial emulation [PDF]

Annals of Intensive Care
Peng Li
doaj   +2 more sources