Results 151 to 160 of about 277,930 (211)

Towards Effective Targeted Alpha Therapy for Neuroendocrine Tumours: A Review. [PDF]

Pharmaceuticals (Basel)
Gape PMD, Schultz MK, Stasiuk GJ, Terry SYA.   +3 more
europepmc   +1 more source

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Advanced Healthcare Materials, EarlyView.
This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar, Daan Vorselen, Jai Prakash   +2 more
wiley   +1 more source

Development of ²²⁵Ac-doped biocompatible nanoparticles for targeted alpha therapy. [PDF]

J Nanobiotechnology
Toro-González M, Akingbesote N, Bible A, Pal D, Sanders B, Ivanov AS, Jansone-Popova S, Popovs I, Benny P, Perry R, Davern S.   +10 more
europepmc   +1 more source

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

Quantitative SPECT/CT imaging of actinium-225 for targeted alpha therapy of glioblastomas. [PDF]

EJNMMI Phys
Tulik M, Kuliński R, Tabor Z, Brzozowska B, Łaba P, Bruchertseifer F, Morgenstern A, Królicki L, Kunikowska J.   +8 more
europepmc   +1 more source

Atom‐Efficient Cerium‐Based Molecular Cages as Biocompatible Reactive Oxygen Scavengers

Advanced Healthcare Materials, EarlyView.
Discrete mixed‐valent cerium molecular cages organize accessible redox centers within confined coordination environments and scavenge superoxide, hydrogen peroxide, and hydroxyl radicals. Encapsulation of the lead cage in an ROS‐responsive DTP nanoplatform enables lesion‐associated delivery, attenuates macrophage oxidative stress and inflammation, and ...
Chao Li, Chunbai Xiang, Ye Xu, Yu Liu, Keze Hong, Fanchu Zeng, Gelin Xu, Zhao‐Xi Wang, Jonathan L. Sessler, Ping Gong   +9 more
wiley   +1 more source

First-in-human SPECT/CT imaging of [²¹¹At]PSMA-5: targeted alpha therapy in a patient with refractory prostate cancer. [PDF]

Eur J Nucl Med Mol Imaging
Watabe T, Hatano K, Naka S, Sasaki H, Kamiya T, Shirakami Y, Toyoshima A, Cardinale J, Giesel FL, Isohashi K, Nonomura N, Tomiyama N.   +11 more
europepmc   +1 more source

Hemocompatible Glycogen‐Tissue Plasminogen Activator Complexes for Enhanced Blood Clot Dissolution

Advanced Healthcare Materials, EarlyView.
Glycogen–heparin‐cRGD nanoparticles enable targeted delivery of tissue plasminogen activator (tPA) to thrombi through activated platelet recognition. The hemocompatible hybrids minimize interactions with blood and immune cells while retaining enzymatic biodegradability.
Nadiia Davydiuk, Vaidehi Londhe, Susanne Boye, Martin Müller, Carsten Werner, Manfred F. Maitz, Quinn A. Besford   +6 more
wiley   +1 more source

Preclinical evaluation of ²²⁵Ac-labeled minigastrin analog DOTA-CCK-66 for Targeted Alpha Therapy. [PDF]

Eur J Nucl Med Mol Imaging
Holzleitner N, Vilangattil M, Swaidan A, Garcia-Prada CD, Taddio MF, Jeanjean P, Mona CE, Lapa C, Casini A, Günther T, Carlucci G.   +10 more
europepmc   +1 more source

Pressure‐Assisted Drug Delivery Using High‐Pressure Balloon Platform Improves Vascular Drug Penetration and Anti‐Restenotic Effects

Advanced Healthcare Materials, EarlyView.
A dual‐layer high‐pressure drug‐coated balloon (HP@DCB) increased balloon‐wall contact and promoted deeper paclitaxel (PTX) penetration than a conventional noncompliant DCB. In in vivo study, HP@DCB treatment improved luminal patency and reduced neointimal hyperplasia, supporting pressure‐assisted drug delivery as a promising strategy for enhancing the
Seung Jin Eo, So Yun Lim, Dong‐Sung Won, Ji Won Kim, Yubeen Park, Song Hee Kim, Hyemin Lee, Jung‐Min Ahn, Jun‐Kyu Park, Do‐Yoon Kang, Jung‐Hoon Park   +10 more
wiley   +1 more source