Results 171 to 180 of about 277,930 (211)

Targeted Alpha Therapy with Thorium-227

Cancer Biotherapy and Radiopharmaceuticals, 2020
Targeted alpha therapy (TAT) can deliver high localized burden of radiation selectively to cancer cells as well as the tumor microenvironment, while minimizing toxicity to normal surrounding cell. Radium-223 ( 223 Ra), the first-in-class α-emitter approved for bone metastatic castration ...
Frantellizzi, Viviana, Cosma, Laura, Brunotti, Gabriele, Pani, Arianna, Spanu, Angela, Nuvoli, Susanna, De Cristofaro, Flaminia, Civitelli, Liana, De Vincentis, Giuseppe   +8 more
openaire   +3 more sources

Targeted Alpha Therapy and Nanocarrier Approach

Cancer Biotherapy and Radiopharmaceuticals, 2020
The rates of cancer incidence and mortality are increasing day by day. Although several conventional methods including surgery, chemotherapy, and radiotherapy (RT) exist for cancer treatment, they are insufficient in the eradication of all tumor tissues and have some side-effects such as narrow therapeutic index and serious side-effects to healthy ...
Silindir Günay, Mine, Özer, Asuman Yekta, Karpuz, Merve   +2 more
openaire   +3 more sources

Targeted Alpha Therapy With 213Bi

Current Radiopharmaceuticals, 2011
The potential of targeted therapy with the alpha emitter 213Bi has been successfully demonstrated in a large number of preclinical studies and several clinical trials have provided evidence for its feasibility, safety and therapeutic efficacy. This review describes methods for the production of 225Ac and 225Ac/213Bi radionuclide generators, gives an ...
Frank Bruchertseifer, Alfred Morgenstern, Christos Apostolidis   +2 more
exaly   +3 more sources

Targeted alpha therapy for cancer

Physics in Medicine and Biology, 2004
Targeted alpha therapy (TAT) offers the potential to inhibit the growth of micrometastases by selectively killing isolated and preangiogenic clusters of cancer cells. The practicality and efficacy of TAT is tested by in vitro and in vivo studies in melanoma, leukaemia, colorectal, breast and prostate cancers, and by a phase 1 trial of intralesional TAT
Barry J, Allen, Chand, Raja, Syed, Rizvi, Yong, Li, Wendy, Tsui, David, Zhang, Emma, Song, Chang Fa, Qu, John, Kearsley, Peter, Graham, John, Thompson   +10 more
openaire   +2 more sources

Radiobiology of Targeted Alpha Therapy

2022
Receptor-targeted radionuclide therapy refers to a form of intravenously administered pharmaceutical cancer treatment that directs radiation specifically to cancer cells in the body. These radiopharmaceuticals generally comprise vectors (or ligands, e.g., antibodies, peptides, small molecules) that are designed to bind to the external domain of cell ...
Schultz, Michael, Pouget, Jean-Pierre, Wuest, Frank, Nelson, Bryce, Andersson, Jan, Cheal, Sarah, Li, Mengshi, Ianzini, Fiorenza, Ray, Sangeeta, Graves, Stephen, Chouin, Nicolas   +10 more
openaire   +3 more sources

Targeted therapy using alpha emitters

Physics in Medicine and Biology, 1996
Radionuclides such as 211At and 212Bi which decay by the emission of alpha-particles are attractive for certain applications of targeted radiotherapy. The tissue penetration of 212Bi and 211At alpha-particles is equivalent to only a few cell diameters, offering the possibility of combining cell-specific targeting with radiation of similar range. Unlike
G, Vaidyanathan, M R, Zalutsky
openaire   +2 more sources

Protein Targeting Constructs in Alpha Therapy

Current Radiopharmaceuticalse, 2011
The progress in the field of targeted α-particle therapy (TAT) has to a great extent been enhanced by developments in both recombinant DNA technology and radionuclide labeling chemistry. Advances in genomics and proteomics have promoted an increase in the identification of novel targets and molecules that can define different diseases, such as cancer ...
Tove, Olafsen, Jorgen, Elgqvist, Anna M, Wu   +2 more
openaire   +2 more sources

Future Prospects for Targeted Alpha Therapy

Current Radiopharmaceuticalse, 2011
The objectives in the application of targeted alpha therapy (TAT) for cancer therapy are reviewed. These relate to elimination of isolated cancer cells, cell clusters and tumors. Requirements for isolated cancer cells are good cellular targeting, high specific activity, and very short range.
openaire   +2 more sources

Production of Alpha Emitters for Targeted Alpha Therapy

Current Radiopharmaceuticalse, 2008
Targeted alpha therapy (TAT) is a promising approach for the treatment of cancer and infectious diseases. The availability of suitable alpha emitting isotopes in clinically relevant amounts is a main prerequisite for further development of TAT and its widespread clinical application.
A. Morgenstern, K. Abbas, F. Bruchertseifer, C. Apostolidis   +3 more
openaire   +1 more source

Advances in targeted alpha therapy of cancer

European Journal of Nuclear Medicine and Molecular Imaging
No abstract available. ; http://link.springer.com/journal/259 ; 2025-02-20 ; hj2024 ; Nuclear Medicine ; SDG-03:Good heatlh and well ...
Sathekge, Mike Machaba, Morgenstern, Alfred   +1 more
openaire   +3 more sources