Results 181 to 190 of about 277,930 (211)
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Preclinical targeted alpha therapy for subcutaneous melanoma
Melanoma Research, 2001An alpha-emitting immunoconjugate (AIC) against malignant melanoma was prepared from the radioisotope bismuth-213 and a melanoma monoclonal antibody, and was used to control the growth of subcutaneous melanoma in a nude mouse model. Activity tolerances were found to be 8 mCi/kg for intraperitoneal injection of the conjugate, and 10 mCi/kg for ...
B J, Allen, S M, Rizvi, Z, Tian
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Targeted Alpha Therapy Using Short-Lived Alpha-Particles and the Promise of Nanobodies as Targeting Vehicle [PDF]
Expert Opinion on Biological Therapy, 2016 The combination of a targeted biomolecule that specifically defines the target and a radionuclide that delivers a cytotoxic payload offers a specific way to destroy cancer cells. Targeted radionuclide therapy (TRNT) aims to deliver cytotoxic radiation to cancer cells and causes minimal toxicity to surrounding healthy tissues.
Nick Devoogdt +2 more
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Clinical Trials of Targeted Alpha Therapy for Cancer
Reviews on Recent Clinical Trials, 2008Targeted alpha therapy is an advancing experimental therapy that holds promise to deliver high cytotoxicity to targeted cancer cells. Initially thought to be indicated for leukaemia and micrometastases, there is now evidence that solid tumours can also be regressed. Alpha therapy may be molecular or physiological in its targeting.
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Potent candidates for Targeted Alpha Therapy (TAT)
Nuclear Medicine and BiologyTargeted Alpha Therapy (TAT) holds significant promise as a localized treatment for cancer. Encouraging clinical results from using peptides and antibodies labeled with alpha emitters to treat patients with metastatic cancers, particularly those who have not responded to other therapies, provide compelling evidence of TAT's potential.
Dmitry, Filosofov +4 more
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The promise of targeted {alpha}-particle therapy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2005The use of monoclonal antibodies to deliver radioisotopes directly to tumor cells has become a promising strategy to enhance the antitumor effects of native antibodies. Since the alpha- and beta-particles emitted during the decay of radioisotopes differ in significant ways, proper selection of isotope and antibody combinations is crucial to making ...
Deborah A, Mulford +2 more
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Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications
Pharmaceutics, 2021Frank Wuest
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Targeted Alpha-Particle Therapy: A Review of Current Trials
International Journal of Molecular Sciences, 2023Thorvardur R Halfdanarson +2 more
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