Targeted drug delivery - Open Access .click

Cancer, 1986
Cancer chemotherapy drugs are neither specific, i.e., they do not act exclusively on the metabolic pathways of cancer cells, nor are they targeted solely toward cancer cells. However, recent research has begun to address, in part, the latter issue. Improved delivery of chemotherapeutic agents to tumor tissue in man appears to be an achievable goal in ...
A I, Freeman, E, Mayhew
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Ligand-Targeted Drug Delivery

Chemical Reviews, 2017
Safety and efficacy constitute the major criteria governing regulatory approval of any new drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic agent with a targeting ligand that exhibits little affinity for healthy cells but high affinity for pathologic cells.
Madduri Srinivasarao, Philip S. Low
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Advances in drug delivery and targeting

Current Opinion in Oncology, 1991
This review covers a variety of techniques aimed at improving the specificity of delivery of both biologic and cytotoxic agents to tumor tissue while sparing normal tissue. The major areas reported on include further attempts to increase the ability of monoclonal antibodies, both conjugated and unconjugated, to target tumor tissue. It also examines the
D, Goldstein, C, Lewis
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Targeted drug delivery to macrophages

Expert Opinion on Drug Delivery, 2013
Targeted drug delivery to the macrophages appears to be an attractive proposition to improve therapeutic efficacy of enclosed drug. Thus, macrophages can be exploited as Trojan horses for targeted drug delivery. Nanocarriers can migrate across the different membrane barriers and release their drug cargo at sites of infection.This review discusses the ...
Narendra K, Jain, Vijay, Mishra, Neelesh Kumar, Mehra +2 more
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cancer
cell-penetrating peptide
sirna

cyclic peptides
cytotoxicity
intracellular transportation

cellular uptake
histidine