Results 241 to 250 of about 7,670,364 (343)

A State‐Gated Metallo‐DNAzyme Framework Programs Tumor Stress Vulnerability Through Metabolic Licensing

Advanced Science, EarlyView.
A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma, Lingyun He, Xinru Wang, Yuanyuan Wei, Chengcheng Li, Jiaqi Yan, Weijian Sun, Xian Shen, Hongbo Zhang   +8 more
wiley   +1 more source

Targeted metabolomics to assess positive effects of empagliflozin in a Parkinson's disease model: focused on the kynurenine pathway and oxidative stress. [PDF]

Sci Rep
Lénárt I, Horváth O, Molnár K, Bereczki C, Monostori P, Klivényi P, Galla Z.   +6 more
europepmc   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

Widely Targeted Metabolomics Reveals Metabolic Differences Between Yellow and Brown Flaxseed Cultivars (<i>Linum usitatissimum</i> L.). [PDF]

Foods
Li W, Sun J, Yang Y, Zhao W, Dang Z, Xie Y, Qi Y, Wang X, Zhang Y, Wang G, Lu N, Niu Y, Hu Z, Wang L, Zhang J.   +14 more
europepmc   +1 more source

Additional file 1 of Metabolic differences among patients with alcohol-related liver disease using targeted and untargeted metabolomics techniques

Jie Lu, Li Zhao, Tianyi Zhu, Yaguang Zhang, Fukun Wang, Ying Xiao   +5 more
openalex   +1 more source

Targeted Metabolomics Reveals Tissue‐Specific Accumulation and Translocation of Bioactive Compounds in Ginger During Growth [PDF]

Yinfeng Zhao, Qin Wang, Jiguang Zhang, Xiuhua Liu, Yixuan Jiang, Qingzhi Li, 尚春华, Min Lin, Rui Weng, Jing Qiu, Yongzhong Qian   +10 more
openalex   +1 more source

Targeting LDHA Palmitoylation Sensitizes GBM to Chemoradiotherapy via Suppressing Palmitic Acid Induced Glycolytic Reprogramming

Advanced Science, EarlyView.
Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao, Rongrong Zhao, Zheyuan Chen, Qingtong Wang, Huanyu Yang, Boyan Li, Yanhua Qi, Shulin Zhao, Jixing Zhao, Jiawei Qiu, Ziwen Pan, Zhe Han, Ruochuan Li, Huize Xia, Weijie Tang, Xing Guo, Ping Zhang, Hongyu Zhao, Xu Qian, Gang Li, Hao Xue   +20 more
wiley   +1 more source

Editorial: Current trends in targeted and non-targeted metabolomics in analytical toxicology

Frontiers in Molecular Biosciences
Geraldine M. Dowling, Geraldine M. Dowling, Geraldine M. Dowling, Markus R. Meyer   +3 more
doaj   +1 more source

Additional file 2 of Metabolic differences among patients with alcohol-related liver disease using targeted and untargeted metabolomics techniques

Jie Lu, Li Zhao, Tianyi Zhu, Yaguang Zhang, Fukun Wang, Ying Xiao   +5 more
openalex   +1 more source

Identification of metabolomics biomarkers of coenzyme Q10 in the improvement of dyslipidemia using serum non-targeted and targeted metabolomics [PDF]

Fang He, Ruijie Wang, Yixuan Xu, Yun Chen, Fuhui Xiang, Zhen Wang, Chunxue Yang, Weimin Xiao, Yichun Wu, Min Luo, Ruifen Zhang, Mingwei Zhang, Yan Yang   +12 more
openalex   +1 more source