Results 261 to 270 of about 7,670,364 (343)

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Non-Targeted Metabolomics Profiling and Anti-Inflammatory Potential of Star Anise Extract in Rats with Cold Stress-Aggravated Acute Lung Injury. [PDF]

Metabolites
Zhang M, Ou M, Wang X, Kou S, Xia X, Fan W, Lu S, Chen Y, Yang X.   +8 more
europepmc   +1 more source

Correction: Xue et al. Untargeted Sweat Metabolomics and Targeted Plasma Amino Acid Profiling Reveal Dynamic Metabolic Remodeling During Conditioning in Yili Horses. Biology 2026, 15, 1033

Yuheng Xue, Penghui Luo, Zhenhui Shen, Chen Meng, Xinkui Yao, Jun Meng, Wanlu Ren, Tongliang Wang, Yaqi Zeng   +8 more
openalex   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Targeted metabolomics of neurotransmitters and tryptophan reveal neuroprotective effect of Dl-3-n-butylphthalide in cerebral ischemia-reperfusion mice

Zixin Wang, Yue Hu, Jiamin Li, Xinyi Wang, Boyi Yuan, Jiameng Li, Yumin Luo, Qingfeng Ma   +7 more
openalex   +1 more source

Allelopathic control of pine needle litter on Ginseng rust rot under forest: Mechanisms uncovered by metabolomics and targeted validation [PDF]

Zibo Li, Xiangyue Cui, Yinan Yu, Zhenqiang Wang, Bing Li, Jingzhi Piao, Rujun Zhou   +6 more
openalex   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Non-targeted metabolomics and postbiotics survey of an Iranian Koupa cheese Lactiplantibacillus plantarum isolate. [PDF]

Sci Rep
Aghabeyk S, Moridi Farimani M, Sadeghi A, Alilou M, Aliahmadi A.   +4 more
europepmc   +1 more source

N-Alkylpyridinium sulfonates as versatile scout compounds for multi-mode highly targeted metabolomics: Application to Gammarus fossarum

Rémy de Boni, Delphine Arquier, Sophie Ayciriex, Arnaud Chaumot, Davide Degli Esposti, Olivier Geffard, Arnaud Salvador   +6 more
openalex   +1 more source

Development and comparative evaluation of chemical ionization and electron ionization for GC–MS targeted metabolomics applied to the brain of a pollinating insect [PDF]

Simon Palmer, Teddy Strandberg, David O'Carroll, Elisa Rigosi, Peter Spégel   +4 more
openalex   +1 more source