Results 251 to 260 of about 7,670,364 (343)

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source

Widely targeted metabolomics of Forsythia suspensa for geographical origin authentication by UPLC-MS/MS combined with chemometrics. [PDF]

BMC Plant Biol
Zheng T, Liu N, Li D, Tang Q, Wang G, Hu Z, Zeng H, Chen T.   +7 more
europepmc   +1 more source

Additional file 3 of Metabolic differences among patients with alcohol-related liver disease using targeted and untargeted metabolomics techniques

Jie Lu, Li Zhao, Tianyi Zhu, Yaguang Zhang, Fukun Wang, Ying Xiao   +5 more
openalex   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

RPLC- and HILIC-based non-targeted metabolomics workflow for blood microsamples. [PDF]

Metabolomics
Couacault P, Witting M.
europepmc   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

Integration of widely targeted and targeted metabolomics reveals flavonoid accumulation profiles across different cultivars of <i>Ludisia discolor</i>. [PDF]

Front Plant Sci
Li L, Yang J, Zhang T, Cai K, Wang F, Yang Q, Lin X, Chen Y, Zheng T.   +8 more
europepmc   +1 more source

Hierarchical Flux‐Protection Engineering Stabilizes Oxidation‐Prone Metabolic Nodes for High‐Level Curcumin Biosynthesis

Advanced Science, EarlyView.
Flux‐protection engineering stabilizes an oxidation‐prone L‐DOPA node in engineered E. coli by combining acid‐adapted chassis evolution, respiratory‐chain modulation, enzyme‐level flux matching, and pH–DO control. Carbon is redirected from oxidative browning to productive biosynthesis, enabling 1075.2 mg/L curcumin and demonstrating transferability to ...
Jianbin Chen, Qihang Chen, Shurong Zhang, Yajuan Su, Xiaoyi Zou, Ke Wang, Shike Liu, Qian He, Liang Zhang, Weizhu Zeng, Jingwen Zhou   +10 more
wiley   +1 more source

Associations between arginine metabolism and gestational diabetes mellitus: an exploratory longitudinal study using widely targeted metabolomics. [PDF]

BMC Pregnancy Childbirth
Li Y, Li Y, Wang J, Ma L, Zhang S, Zhao W, Sun Y.   +6 more
europepmc   +1 more source

MassIVE MSV000103193 - 20260911 Mouse cecal contents targeted and untargeted metabolomics

Robert Michael Sargis
openalex   +1 more source