Results 21 to 30 of about 3,528,989 (183)
Targeted Radionuclide Therapy: A Theranostic Approach to Cancer Therapy. [PDF]
Clin J Oncol NursTargeted radionuclide therapy is a rapidly progressing therapy that offers an individualized approach to cancer treatment by using radioisotopes (radiation) that are created specifically to help visualize with imaging and/or.
Davis ME, Longing A.
europepmc +4 more sources
Application of the Linear-Quadratic model to targeted radionuclide therapy [PDF]
, 2011 PhDThe principal aim of this work was to test the hypothesis that the Linear-Quadratic (LQ) model of cell survival, developed for external beam radiotherapy (EBRT), could be extended to targeted radionuclide therapy (TRT) in order to predict dose ...
Murray, Iain
core +4 more sources
Targeted radionuclide therapies for pancreatic cancer [PDF]
Cancer Gene Therapy, 2015 Pancreatic malignancies, the fourth leading cause of cancer deaths, have an aggressive behavior with poor prognosis, resulting in a 5-year survival rate of only 4%. It is typically a silent malignancy until patients develop metastatic disease. Targeted radionuclide therapies of cancer such as radiolabeled peptides, which bind to the receptors ...
M, Shah +5 more
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Targeting Melanin in Melanoma with Radionuclide Therapy
International Journal of Molecular Sciences, 2022 Nearly 100,000 individuals are expected to be diagnosed with melanoma in the United States in 2022. Treatment options for late-stage metastatic disease up until the 2010s were few and offered only slight improvement to the overall survival. The introduction of B-RAF inhibitors and anti-CTLA4 and anti-PD-1/PD-L1 immunotherapies into standard of care ...
Kevin J. H. Allen +3 more
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What is the role of the bystander response in radionuclide therapies?
Frontiers in Oncology, 2013 Radionuclide therapy for cancer is undergoing a renaissance, with a wide range of radionuclide and clinical delivery systems currently under investigation.
Darren eBrady +2 more
doaj +1 more source
Combination Therapies with PRRT
Pharmaceuticals, 2021 Peptide receptor radionuclide therapy (PRRT) is a successful targeted radionuclide therapy in neuroendocrine tumors (NETs). However, complete responses remain elusive.
Anna Yordanova, Hojjat Ahmadzadehfar
doaj +1 more source
Recent Innovations and Nano-Delivery of Actinium-225: A Narrative Review
Pharmaceutics, 2023 The actinium-225 (225Ac) radioisotope exhibits highly attractive nuclear properties for application in radionuclide therapy. However, the 225Ac radionuclide presents multiple daughter nuclides in its decay chain, which can escape the targeted site ...
Sipho Mdanda +4 more
doaj +1 more source
Combination Strategies to Improve Targeted Radionuclide Therapy [PDF]
Journal of Nuclear Medicine, 2020 In recent years, targeted radionuclide therapy (TRT) has emerged as a promising strategy for cancer treatment. In contrast to conventional radiotherapy, TRT delivers ionizing radiation to tumors in a targeted manner, reducing the dose that healthy tissues are exposed to.
Chan, T +3 more
openaire +3 more sources
Preclinical Evaluation of PTK7-Targeted Radionuclide Therapy. [PDF]
Mol Cancer TherAbstract Protein tyrosine kinase 7 (PTK7), a receptor found in tumor-initiating cells, is expressed in various malignancies, including ovarian cancer. While PTK7 has been explored as a target for antibody-drug conjugates, this study is the first to investigate its potential for targeted radionuclide therapy.
Lindland K +7 more
europepmc +4 more sources
Production of Sm-153 With Very High Specific Activity for Targeted Radionuclide Therapy
Frontiers in Medicine, 2021 Samarium-153 (153Sm) is a highly interesting radionuclide within the field of targeted radionuclide therapy because of its favorable decay characteristics.
Michiel Van de Voorde +15 more
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