Results 161 to 170 of about 1,011,686 (269)

Membrane heat shock protein 70: a theranostic target for cancer therapy [PDF]

, 2017
Maxim Shevtsov, Huile Gao, Gabriele Multhoff   +2 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The Evolving Interplay Between Targeted Therapy and Surgery for Resectable Lung Cancer. [PDF]

Cancers (Basel)
Yin V, Antonoff MB.
europepmc   +1 more source

Transforming the Management of Oligometastatic Non-Small Cell Lung Cancer in the Era of Immunotherapy and Targeted Therapy

Yohei Kawaguchi, Satoshi Takahashi, Yoshihisa Shimada, Yujin Kudo, Norihiko Ikeda   +4 more
openalex   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Progress and prospects of gut microbiota-targeted therapy for primary biliary cholangitis. [PDF]

Gut Pathog
Tang X, You X.
europepmc   +1 more source

RES and brain targeting stavudine-loaded solid lipid nanoparticles for AIDS therapy

, 2012
Panchaxari M. Dandagi, Punit D Patel, Anand Panchakshari Gadad, Anil Kumar Aravapalli   +3 more
openalex   +2 more sources

Mechanisms of resistance to EGFR targeted therapies [PDF]

, 2013
Gorjan Hrustanovic, Bianca J. Lee, Trever G. Bivona   +2 more
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Repurposing Carfilzomib as a Promising Drug for Targeted Therapy in Gastric Cancer. [PDF]

Cancers (Basel)
Kurstjens EM, Cox KE, Bali P, Amirfakhri S, Hernandez J, Lozano-Pope I, Benner C, Bouvet M, Obonyo M.   +8 more
europepmc   +1 more source