Results 231 to 240 of about 10,998,800 (355)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Genomic analysis unlocks the potential of denosumab as a targeted therapy for Crohn's disease. [PDF]

Sci Rep
Pranata R, Ratnasari N, Bayupurnama P, Indrarti F, Aulia N, Rahmawati H, Adikusuma W, Mugiyanto E, Irham LM, Gunarto C, Alya SS, Hadi VF, Sentosa GC, Wahyuningsih AT, Lin CF, Satria RD.   +15 more
europepmc   +1 more source

MET-dependent solid tumours — molecular diagnosis and targeted therapy

Nature Reviews Clinical Oncology, 2020
Robin Guo, Jia Luo, Jason C. Chang, N. Rekhtman, M. Arcila, A. Drilon   +5 more
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Cutaneous lupus erythematosus - from pathogenesis to targeted therapy. [PDF]

Nat Rev Rheumatol
Klein B, Billi AC, Abernathy-Close L, Kahlenberg JM.   +3 more
europepmc   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Breast Cancer: Molecular Pathogenesis, Targeted Therapy, Screening, and Prevention. [PDF]

MedComm (2020)
Lei H, Fu J, Gu W, Qiao H, Guo H, Chen Z, Wang SM, Chen T.   +7 more
europepmc   +1 more source

Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy

Cell, 2020
Karsten Krug, Eric J. Jaehnig, S. Satpathy, L. Blumenberg, A. Karpova, M. Anurag, George Miles, Philipp Mertins, Philipp Mertins, Y. Geffen, Lauren C. Tang, Lauren C. Tang, David I Heiman, Song Cao, Y. Maruvka, Jonathan T. Lei, Chen Huang, Ramani Kothadia, A. Colaprico, Chet Birger, Jarey H. Wang, Yongchao Dou, Bo Wen, Zhiao Shi, Yuxing Liao, M. Wiznerowicz, M. Wiznerowicz, Matthew A. Wyczalkowski, Xi Steven Chen, Jacob J. Kennedy, A. Paulovich, M. Thiagarajan, C. Kinsinger, Tara Hiltke, Emily Boja, M. Mesri, A. Robles, H. Rodriguez, Thomas F. Westbrook, L. Ding, G. Getz, G. Getz, K. Clauser, D. Fenyö, Kelly V. Ruggles, Bing Zhang, D. Mani, Steve Carr, M. Ellis, Michael A. Gillette, Michael A. Gillette, S. Avanessian, S. Cai, Daniel W. Chan, Xian Chen, N. Edwards, A. Hoofnagle, M. H. Kane, K. Ketchum, E. Kuhn, D. Levine, Shunqiang Li, D. Liebler, Tao Liu, Jingqin R Luo, Subha Madhavan, Christopher G. Maher, J. Mcdermott, P. McGarvey, Mauricio Oberti, A. Pandey, S. Payne, D. Ransohoff, Robert C. Rivers, K. Rodland, P. Rudnick, M. Sanders, K. Shaw, I. Shih, R. Slebos, Richard D. Smith, Michael Snyder, S. Stein, D. Tabb, Ratna R. Thangudu, Stefani N. Thomas, Yue Wang, F. White, Jeffrey R. Whiteaker, Gordon A. Whiteley, Hui Zhang, Zhen Zhang, Yingming Zhao, Hengying Zhu, L. Zimmerman   +94 more
semanticscholar   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Targeted therapy in patients with genetic tumor syndromes. [PDF]

Med Genet
Jahn A, Heining C, Fröhling S, Glimm H, Schröck E.   +4 more
europepmc   +1 more source