Results 61 to 70 of about 10,998,800 (355)

Optimizing survival outcomes with post-remission therapy in acute myeloid leukemia. [PDF]

, 2019
Optimization of post-remission therapies to maintain complete remission and prevent relapse is a major challenge in treating patients with acute myeloid leukemia (AML).
Chan, Steven M, Daver, Naval G, Jonas, Brian A, Medeiros, Bruno C, Pollyea, Daniel A   +4 more
core   +1 more source

NF-κB in biology and targeted therapy: new insights and translational implications

Signal Transduction and Targeted Therapy
NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses.
Qing Guo, Yizi Jin, Xinyu Chen, Xiaomin Ye, Xin Shen, Mingxi Lin, C. Zeng, Teng Zhou, Jian Zhang   +8 more
semanticscholar   +1 more source

Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects

Signal Transduction and Targeted Therapy, 2020
Based on engineered or bacterial nucleases, the development of genome editing technologies has opened up the possibility of directly targeting and modifying genomic sequences in almost all eukaryotic cells.
Hongyi Li, Yang Yang, Weiqi Hong, Mengyuan Huang, Min Wu, Xia Zhao   +5 more
semanticscholar   +1 more source

Recist and targeted therapy [PDF]

Acta Radiologica, 2009
Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract.
openaire   +3 more sources

Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy

Signal Transduction and Targeted Therapy
Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide. Its complexity is influenced by various signal transduction networks that govern cellular proliferation, survival, differentiation, and apoptosis.
Qing Li, Shan Geng, Hao Luo, Wei Wang, Ya-Qi Mo, Qing Luo, Lu Wang, Guanbin Song, Jian-Peng Sheng, Bo Xu   +9 more
semanticscholar   +1 more source

ALKBH5-mediated m6A demethylation of GLUT4 mRNA promotes glycolysis and resistance to HER2-targeted therapy in breast cancer.

Cancer Research, 2022
Resistance to HER2-targeted therapy represents a significant challenge for the successful treatment of breast cancer patients with HER2-positive tumors.
H. Liu, H. Lyu, Guanmin Jiang, Danyang Chen, S. Ruan, Shuang Liu, Lukun Zhou, Mingqiang Yang, Shanshan Zeng, Zhiming He, Hongsheng Wang, Hongsheng Li, G. Zheng, Bolin Liu   +13 more
semanticscholar   +1 more source

Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy

Frontiers in Oncology, 2022
Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis.
Yuheng Zou, Hongying Zhang, Feng Bi, Qiulin Tang, Huanji Xu   +4 more
doaj   +1 more source

Local generation of hydrogen for enhanced photothermal therapy. [PDF]

, 2018
By delivering the concept of clean hydrogen energy and green catalysis to the biomedical field, engineering of hydrogen-generating nanomaterials for treatment of major diseases holds great promise.
Chen, Danyang, Chen, Qian, Gu, Zhen, He, Qianjun, Jin, Zhaokui, Lu, Xifeng, Meng, Jin, Yang, Tian, Zhao, Penghe   +8 more
core   +2 more sources

Cold and hot tumors: from molecular mechanisms to targeted therapy

Signal Transduction and Targeted Therapy
Immunotherapy has made significant strides in cancer treatment, particularly through immune checkpoint blockade (ICB), which has shown notable clinical benefits across various tumor types.
Bo Wu, Bo Zhang, Bowen Li, Haoqi Wu, Mei-feng Jiang   +4 more
semanticscholar   +1 more source

Ribosomal proteins and human diseases: molecular mechanisms and targeted therapy

Signal Transduction and Targeted Therapy, 2021
Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the ribosome, are essential for ribosome assembly and function.
Jian Kang, Natalie Brajanovski, Keefe T. Chan, Jiachen Xuan, R. Pearson, E. Sanij   +5 more
semanticscholar   +1 more source