Results 241 to 250 of about 156,135 (285)

Sepsis and the diverse organ-gastrointestinal tract axis. [PDF]

open access: yesWorld J Crit Care Med
Wang JDJ, Suan E, Li SS, Shelat VG.
europepmc   +1 more source

Clinical trials of targeted toxins

Seminars in Cancer Biology, 1995
Immunotoxins (monoclonal antibodies chemically coupled to peptide toxins) and fusion toxins (peptide ligands fused genetically to peptide toxins) have been used to treat a variety of malignancies over the last 20 years. Problems with normal tissue toxicities (vascular leak syndrome, hepatotoxicity, and neurotoxicities), poor penetration to tumor ...
Edward Tagge
exaly   +3 more sources

Targeting Bacterial Toxins

Angewandte Chemie International Edition, 2012
AbstractProtein toxins constitute the main virulence factors of several species of bacteria and have proven to be attractive targets for drug development. Lead candidates that target bacterial toxins range from small molecules to polymeric binders, and act at each of the multiple steps in the process of toxin‐mediated pathogenicity.
Mattias E, Ivarsson   +2 more
openaire   +4 more sources

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