Results 241 to 250 of about 1,199,889 (280)
Early Treatment of Post-Stroke Spasticity with Botulinum Toxin Type A: Myth or Reality? [PDF]
Toxins (Basel)Picelli A +4 more
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The Gut-Kidney-Metabolic Axis: Impact of Gut-Derived Uremic Toxins on Insulin Resistance in Diabetic Kidney Disease. [PDF]
Int J Mol SciDelrue C +4 more
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Journal of Oncology Pharmacy Practice, 1999
Objective. Current modalities used in the treatment of cancer often cause unacceptable damage to normal tissue. Toxins targeted toward tumor cells by antibodies or growth factors have the potential to selectively kill tumor cells while leaving normal tissue intact.
G C de Gast
exaly +2 more sources
Objective. Current modalities used in the treatment of cancer often cause unacceptable damage to normal tissue. Toxins targeted toward tumor cells by antibodies or growth factors have the potential to selectively kill tumor cells while leaving normal tissue intact.
G C de Gast
exaly +2 more sources
Clinical trials of targeted toxins
Seminars in Cancer Biology, 1995Immunotoxins (monoclonal antibodies chemically coupled to peptide toxins) and fusion toxins (peptide ligands fused genetically to peptide toxins) have been used to treat a variety of malignancies over the last 20 years. Problems with normal tissue toxicities (vascular leak syndrome, hepatotoxicity, and neurotoxicities), poor penetration to tumor ...
Arthur Frankel +2 more
exaly +3 more sources
Diphtheria toxin-based targeted toxins that target glioblastoma multiforme
Toxin Reviews, 2014AbstractTargeted toxins (TTs) are compounds that bind cell surface receptors overexpressed on cancer cells. After the molecule enters the cell, the toxin component migrates to the ribosomes where it blocks protein synthesis killing the cell. Most of these proteins are recombinant and contain a carrier ligand or antibody attached to a modified bacterial
Daniel Vallera, Yan Michael Li
exaly +2 more sources
Current Protocols in Neuroscience, 2001
AbstractMolecular neurosurgery can be used to make selective neural lesions by targeting cytotoxins to specific populations of neurons based on their common expression of a particular surface molecule. The targeted toxins employed in this unit consist of a targeting moiety (vector) and an effector moiety (cytotoxin). In all cases discussed in this unit,
R G, Wiley, D A, Lappi
openaire +2 more sources
AbstractMolecular neurosurgery can be used to make selective neural lesions by targeting cytotoxins to specific populations of neurons based on their common expression of a particular surface molecule. The targeted toxins employed in this unit consist of a targeting moiety (vector) and an effector moiety (cytotoxin). In all cases discussed in this unit,
R G, Wiley, D A, Lappi
openaire +2 more sources
Advanced Drug Delivery Reviews, 2003
Although only recently applied to the study of nociception, 'molecular neurosurgery', producing highly selective neural lesions using targeted cytotoxins, has proven a valuable tool for analysis of nociceptive systems and promises to yield much more information on the role of specific types of neurons in pain perception and possibly new pain therapies.
Ronald G, Wiley, Douglas A, Lappi
openaire +2 more sources
Although only recently applied to the study of nociception, 'molecular neurosurgery', producing highly selective neural lesions using targeted cytotoxins, has proven a valuable tool for analysis of nociceptive systems and promises to yield much more information on the role of specific types of neurons in pain perception and possibly new pain therapies.
Ronald G, Wiley, Douglas A, Lappi
openaire +2 more sources
Angewandte Chemie International Edition, 2012
AbstractProtein toxins constitute the main virulence factors of several species of bacteria and have proven to be attractive targets for drug development. Lead candidates that target bacterial toxins range from small molecules to polymeric binders, and act at each of the multiple steps in the process of toxinâmediated pathogenicity.
Ivarsson ME, Leroux JC, Castagner B
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AbstractProtein toxins constitute the main virulence factors of several species of bacteria and have proven to be attractive targets for drug development. Lead candidates that target bacterial toxins range from small molecules to polymeric binders, and act at each of the multiple steps in the process of toxinâmediated pathogenicity.
Ivarsson ME, Leroux JC, Castagner B
openaire +3 more sources
Diphtheria toxin-based targeted toxin therapy for brain tumors
Journal of Neuro-Oncology, 2013Targeted toxins (TT) are molecules that bind cell surface antigens or receptors such as the transferrin or interleukin-13 receptor that are overexpressed in cancer. After internalization, the toxin component kills the cell. These recombinant proteins consist of an antibody or carrier ligand coupled to a modified plant or bacterial toxin such as ...
Yan Michael, Li +2 more
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