Results 251 to 260 of about 156,135 (285)
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Current Protocols in Neuroscience, 2001
AbstractMolecular neurosurgery can be used to make selective neural lesions by targeting cytotoxins to specific populations of neurons based on their common expression of a particular surface molecule. The targeted toxins employed in this unit consist of a targeting moiety (vector) and an effector moiety (cytotoxin). In all cases discussed in this unit,
R G, Wiley, D A, Lappi
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AbstractMolecular neurosurgery can be used to make selective neural lesions by targeting cytotoxins to specific populations of neurons based on their common expression of a particular surface molecule. The targeted toxins employed in this unit consist of a targeting moiety (vector) and an effector moiety (cytotoxin). In all cases discussed in this unit,
R G, Wiley, D A, Lappi
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Advanced Drug Delivery Reviews, 2003
Although only recently applied to the study of nociception, 'molecular neurosurgery', producing highly selective neural lesions using targeted cytotoxins, has proven a valuable tool for analysis of nociceptive systems and promises to yield much more information on the role of specific types of neurons in pain perception and possibly new pain therapies.
Ronald G, Wiley, Douglas A, Lappi
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Although only recently applied to the study of nociception, 'molecular neurosurgery', producing highly selective neural lesions using targeted cytotoxins, has proven a valuable tool for analysis of nociceptive systems and promises to yield much more information on the role of specific types of neurons in pain perception and possibly new pain therapies.
Ronald G, Wiley, Douglas A, Lappi
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Journal of Oncology Pharmacy Practice, 1999
Objective. Current modalities used in the treatment of cancer often cause unacceptable damage to normal tissue. Toxins targeted toward tumor cells by antibodies or growth factors have the potential to selectively kill tumor cells while leaving normal tissue intact.
M W J den Brok +3 more
exaly +2 more sources
Objective. Current modalities used in the treatment of cancer often cause unacceptable damage to normal tissue. Toxins targeted toward tumor cells by antibodies or growth factors have the potential to selectively kill tumor cells while leaving normal tissue intact.
M W J den Brok +3 more
exaly +2 more sources
Diphtheria toxin-based targeted toxins that target glioblastoma multiforme
Toxin Reviews, 2014AbstractTargeted toxins (TTs) are compounds that bind cell surface receptors overexpressed on cancer cells. After the molecule enters the cell, the toxin component migrates to the ribosomes where it blocks protein synthesis killing the cell. Most of these proteins are recombinant and contain a carrier ligand or antibody attached to a modified bacterial
Walter A. Hall +2 more
exaly +2 more sources
Diphtheria toxin-based targeted toxin therapy for brain tumors
Journal of Neuro-Oncology, 2013Targeted toxins (TT) are molecules that bind cell surface antigens or receptors such as the transferrin or interleukin-13 receptor that are overexpressed in cancer. After internalization, the toxin component kills the cell. These recombinant proteins consist of an antibody or carrier ligand coupled to a modified plant or bacterial toxin such as ...
Yan Michael, Li +2 more
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Peptide Toxins Targeting KV Channels
2021A number of peptide toxins isolated from animals target potassium ion (K+) channels. Many of them are particularly known to inhibit voltage-gated K+ (KV) channels and are mainly classified into pore-blocking toxins or gating-modifier toxins. Pore-blocking toxins directly bind to the ion permeation pores of KV channels, thereby physically occluding them.
Kazuki, Matsumura +2 more
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Targeted Toxin Therapy for the Treatment of Cancer
JNCI Journal of the National Cancer Institute, 1989Protein toxins such as Pseudomonas exotoxin, diphtheria toxin, and ricin may be useful in cancer therapy because they are among the most potent cell-killing agents. One molecule of a toxin delivered to the cytoplasm of a cancer cell will be lethal for that cell.
D, FitzGerald, I, Pastan
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Targeted toxins as anticancer agents
Cancer, 1994Transformed cells, such as those found in breast cancer, often overexpress a variety of cell surface receptors and antigens. Antibodies or growth factors that specifically recognize these membrane-bound structures can be linked with protein toxins, resulting in cell-specific cytotoxic reagents.
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Targeting toxins to neural antigens and receptors
Seminars in Cancer Biology, 1996Immunotoxins have been used to study the targeting of biologically active substances at neurons in vivo and to make experimental neural lesions. OX7-saporin, directed against Thy 1, destroys any neuron. 192 IgG-saporin, directed against the 'low affinity' neurotrophin receptor (p 75NTR), selectively destroys neurons expressing this receptor ...
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Clinical cancer research : an official journal of the American Association for Cancer Research, 2000
Targeted toxins, consisting of tumor-selective ligands coupled to polypeptide toxins, represent a new class of cancer therapeutics that kills malignant cells by inactivating cytosolic protein synthesis and inducing apoptosis. A number of these molecules have been produced under good manufacturing practice conditions and given systemically to patients ...
A E, Frankel +2 more
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Targeted toxins, consisting of tumor-selective ligands coupled to polypeptide toxins, represent a new class of cancer therapeutics that kills malignant cells by inactivating cytosolic protein synthesis and inducing apoptosis. A number of these molecules have been produced under good manufacturing practice conditions and given systemically to patients ...
A E, Frankel +2 more
openaire +1 more source