Results 121 to 130 of about 927,175 (307)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

El papel de los alumnos en el proceso de selección, creación e implementación de materiales [PDF]

marcoELE. Revista de Didáctica Español Lengua Extranjera, 2009
En el presente artículo se describe una experiencia didáctica llevada a cabo por los autores y que pretendió fomentar la implicación del alumno de E/LE (niveles B1-C1) en los procesos de planificación y creación de materiales de su curso. Partiendo de la
Lozano López, Gracia , Sánchez Cuadrado, Adolfo   +1 more
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Student perceived effectiveness of task-based instructional design of data-driven synonym learning featuring “mini-lecture”

Journal of China Computer-Assisted Language Learning
This study evaluates student perceived effectiveness of a guided inductive approach for synonym learning through a 36-week, two-round data-driven learning (DDL) and task-based instruction design.
Yang Yingying, Chen Lin, Tian Xumin
doaj   +1 more source

Lessons Learned in a Math Excel Workshop: The Importance of Maintaining High Cognitive Demands [PDF]

, 2003
Uri Treisman\u27s Emerging Scholars Workshop model has been implemented on many college campuses over the last twenty years. The Treisman model is based on groups of students meeting regularly in a social atmosphere to work collaboratively in solving ...
Dick, T.
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Engaging Students Through Task-Based Language Instruction

, 2017
BRIEF SESSION DESCRIPTION: Task-Based Language Teaching (TBLT) is a theoretical and pedagogical framework that originates from the field of second language acquisition in which the construct of task informs syllabus design as well as classroom instruction.
Dudnik, Natalia, Serafini, Ellen, Bonilla, Carrie, Chen, Xi, Romaniuc, Raluca, Guglielmi, Helen   +5 more
openaire   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

The perceptions of KUIM’s (Kolej Universiti Islam Malaysia) first year undergraduates in learning English using ‘tell me more’ software [PDF]

, 2007
The use of technology in language learning has expanded rapidly worldwide during the last few decades. Studies on the effects of technology enhanced instruction on achievement and studies on students’ attitudes regarding learning with technology have ...
Zakaria, Zarina Ashikin
core