Results 121 to 130 of about 188,887 (312)

Impact of Task-based and Task-supported L2 Teaching on the Use of Connective Markers in Learners’ Written Performance

Theory and Practice of Second Language Acquisition
The current study investigates the impact of two types of instruction on teaching connective markers in learners' written performance. 82 EFL learners were assigned to two experimental groups (EG1, N = 29 and EG2, N = 25) and one control group (CG, N ...
Tomasz Róg, Artur Urbaniak
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Content-Based Language Instruction in Second/Foreign Language Programs [PDF]

, 1998
The purpose of this paper is to provide an overview of content-based instruction and then to discuss the benefits of such an approach in the acquisition of second language.
Cunliffe, Brenda
core  

El papel de los alumnos en el proceso de selección, creación e implementación de materiales [PDF]

marcoELE. Revista de Didáctica Español Lengua Extranjera, 2009
En el presente artículo se describe una experiencia didáctica llevada a cabo por los autores y que pretendió fomentar la implicación del alumno de E/LE (niveles B1-C1) en los procesos de planificación y creación de materiales de su curso. Partiendo de la
Lozano López, Gracia , Sánchez Cuadrado, Adolfo   +1 more
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Student perceived effectiveness of task-based instructional design of data-driven synonym learning featuring “mini-lecture”

Journal of China Computer-Assisted Language Learning
This study evaluates student perceived effectiveness of a guided inductive approach for synonym learning through a 36-week, two-round data-driven learning (DDL) and task-based instruction design.
Yang Yingying, Chen Lin, Tian Xumin
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Theorising tertiary writing instruction: Accounting for the process, post-process, genre and critical literacies approaches [PDF]

, 2008
This discussion of theories of writing instruction arises from the context of teaching research writing to postgraduate students for whom English is an additional language.
Bruce, Ian
core  

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source