Results 121 to 130 of about 478,616 (367)

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

Towards an Electronic Dog Nose: Surface Plasmon Resonance Immunosensor for Security and Safety

open access: yesSensors, 2014
This review describes an “electronic dog nose” based on a surface plasmon resonance (SPR) sensor and an antigen–antibody interaction for security and safety.
Takeshi Onodera, Kiyoshi Toko
doaj   +1 more source

TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2018
Significance It is currently thought that the transduction of bitter, sweet, and umami stimuli in taste cells depends on G protein-coupled receptor signaling with transient receptor potential melastatin 5 (TRPM5) acting as a common downstream component ...
Debarghya Dutta Banik   +4 more
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Functional connectivity differences in healthy individuals with different well-being states

open access: yesNeuroscience Informatics, 2023
Well-being (WB) is defined as a healthy state of mind and body. It is a state in which an individual is able to contribute to its society, able to work productively and overcome the normal stress of life.
Akshita Joshi   +6 more
doaj  

Taste Quality Representation in the Human Brain

open access: yesJournal of Neuroscience, 2019
In the mammalian brain, the insula is the primary cortical substrate involved in the perception of taste. Recent imaging studies in rodents have identified a “gustotopic” organization in the insula, whereby distinct insula regions are selectively ...
Jason A. Avery   +5 more
semanticscholar   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

A taste for diversity

open access: yes, 2019
Something we can call “European food culture” does exist, from the time when a “European” cultural unit came into existence – that is, from the Middle Ages on. From then until today, European culture has taken on a perfectly recognizable identity, a “common taste” resting on local/regional diversities, always showing a common heritage, always changing ...
openaire   +2 more sources

The taste of water

open access: yeseLife, 2019
Female mosquitos require a specific ion-channel protein to sense the presence of fresh water in which they can lay their eggs.
openaire   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

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