Results 211 to 220 of about 268,731 (242)
The FEBS Journal, EarlyView.This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley +1 more source
Ploidy‐dependent modulation of DNA replication kinetics in Xenopus
The FEBS Journal, EarlyView.Using an interspecies replication system with Xenopus frog species of different ploidy levels, we investigated how DNA replication adapts to polyploidization. While replication was slower in tetraploid than in diploid nuclei, dodecaploid nuclei unexpectedly replicated faster than tetraploid nuclei. Our findings show that increasing genome size does not
Hemalatha Narassimprakash +4 more
wiley +1 more source
The FEBS Journal, EarlyView.RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas +4 more
wiley +1 more source
RLIM‐associated neurodevelopmental disorders: From clinical spectrum to molecular mechanisms
The FEBS Journal, EarlyView.RLIM (RNF12) is an E3 ubiquitin ligase essential for mammalian development. Loss‐of‐function variants cause Tønne–Kalscheuer syndrome, while duplications cause Xq13 duplication syndrome, highlighting RLIM dosage sensitivity. This review summarizes the genetics, clinical features, and molecular mechanisms of RLIM‐associated disorders, integrating ...
Madison Landon +4 more
wiley +1 more source
Financial Management, EarlyView.ABSTRACT Diversity, equity, and inclusion (DEI) is one of the most polarizing issues in business and society. Advocates claim that DEI enhances fairness, while critics argue it undermines meritocracy. The problems often stem from the practice of DEI—reducing it to demographic diversity—rather than its principle.
Alex Edmans
wiley +1 more source
Metabolomics and electronic tongue analysis show taste differences in Juhong tea from various black tea sources. [PDF]
Food Chem XGui A +13 more
europepmc +1 more source
Histopathology, EarlyView.This meta‐analysis demonstrates that high‐grade tumour budding is an independent prognostic factor in stage II–III colorectal cancer, associated with significantly worse disease‐free survival, overall survival and cancer‐specific survival. Aims Tumour budding (TB) has been recognized as an additional prognostic factor in the TNM (2017) and WHO (2019 ...
Yao Shu +4 more
wiley +1 more source
Insect Conservation and Diversity, EarlyView.A capture–mark–recapture study in 2025 revealed a metapopulation with a pronounced core–peripheral structure and substantial differences in local population size and phenology. Most imagines remained within local host plant patches, but rare long‐distance movements by females maintain functional connectivity among colonies.
Paulo von der Wense Goncalves +5 more
wiley +1 more source