Results 41 to 50 of about 102,975 (341)

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds. [PDF]

PLoS ONE, 2012
Recent studies suggest that l-glutamate may be an efferent transmitter released from axons innervating taste buds. In this report, we determined the types of ionotropic synaptic glutamate receptors present on taste cells and that underlie this postulated
Yijen A Huang, Jeff Grant, Stephen Roper
doaj   +1 more source

Transcriptome dataset for RNA-seq analysis of axolotl embryonic oropharyngeal endoderm explants

Data in Brief, 2020
Animal nutrition and toxin deterrence rely on the ability to taste, which occurs through columnar taste cells clustered within taste buds. Taste buds in mammals are located within specialized tissues, called papillae.
Lauren Marazzi, Priya Kohli, Deborah Eastman   +2 more
doaj   +1 more source

Unilateral nasal obstruction induces degeneration of fungiform and circumvallate papillae in rats

Journal of the Formosan Medical Association, 2018
In clinical orthodontic treatment, chronic respiratory disturbance or mouth breathing has been concerned symptoms and screening criteria. In this study, to analyze the relation between nasal obstruction and taste sensing, a unilateral nasal obstruction ...
Jui-Chin Hsu, Ippei Watari, Yukiha Funaki, Satoshi Kokai, Takashi Ono   +4 more
doaj   +1 more source

Fingerprinting taste buds: intermediate filaments and their implication for taste bud formation [PDF]

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2000
Intermediate filaments in taste organs of terrestrial (human and chick) as well as aquatic (Xenopus laevis) species were detected using immunohistochemistry and electron microscopy. During development, the potential importance of the interface between the taste bud primordium and non–gustatory, adjacent tissues is evidenced by the distinct ...
M, Witt, K, Reutter, D, Ganchrow, J R, Ganchrow   +3 more
openaire   +2 more sources

Suspension-cultured taste bud organoids recapitulate taste buds

Organoid, 2023
Background Taste buds are a complex organ and require a plethora of growth factors for their development, homeostasis, and regeneration. Taste bud organoids provide a platform for understanding their development, disease and regeneration. Methods In this study, we focused on identifying the localization of receptors involved during taste bud ...
Anish Ashok Adpaikar, Jong-Min Lee, Han-Sung Jung   +2 more
openaire   +1 more source

A taste for ATP: neurotransmission in taste buds [PDF]

Frontiers in Cellular Neuroscience, 2013
Not only is ATP a ubiquitous source of energy but it is also used widely as an intercellular signal. For example, keratinocytes release ATP in response to numerous external stimuli including pressure, heat, and chemical insult. The released ATP activates purinergic receptors on nerve fibers to generate nociceptive signals.
Kinnamon, Sue C., Finger, Thomas E.
openaire   +3 more sources

Contribution of Underlying Connective Tissue Cells to Taste Buds in Mouse Tongue and Soft Palate. [PDF]

PLoS ONE, 2016
Taste buds, the sensory organs for taste, have been described as arising solely from the surrounding epithelium, which is in distinction from other sensory receptors that are known to originate from neural precursors, i.e., neural ectoderm that includes ...
Kristin Boggs, Nandakumar Venkatesan, Ingmar Mederacke, Yoshihiro Komatsu, Steve Stice, Robert F Schwabe, Charlotte M Mistretta, Yuji Mishina, Hong-Xiang Liu   +8 more
doaj   +1 more source

Cellular mechanisms of taste disturbance induced by the non-steroidal anti-inflammatory drug, diclofenac, in mice

Frontiers in Cellular Neuroscience, 2023
Drug-induced taste disorders are a serious problem in an aging society. This study investigated the mechanisms underlying taste disturbances induced by diclofenac, a non-steroidal anti-inflammatory drug that reduces pain and inflammation by inhibiting ...
Ayaka Hirayama, Ayaka Hirayama, Shusuke Iwata, Asami Oike, Yuko Kawabata, Yuki Nagasato, Shingo Takai, Keisuke Sanematsu, Keisuke Sanematsu, Keisuke Sanematsu, Ichiro Takahashi, Noriatsu Shigemura, Noriatsu Shigemura   +12 more
doaj   +1 more source