Results 1 to 10 of about 2,584,981 (353)

Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor. [PDF]

Mol Nutr Food Res, 2023
SCOPE To avoid ingestion of potentially harmful substances humans are equipped with about 25 bitter taste receptor genes (TAS2R) expressed in oral taste cells.
Lang T, Di Pizio A, Risso D, Drayna D, Behrens M.   +4 more
europepmc   +2 more sources

Artificial Sweeteners Disrupt Tight Junctions and Barrier Function in the Intestinal Epithelium through Activation of the Sweet Taste Receptor, T1R3 [PDF]

Nutrients, 2020
The breakdown of the intestinal epithelial barrier and subsequent increase in intestinal permeability can lead to systemic inflammatory diseases and multiple-organ failure.
Aparna Shil, Oluwatobi Olusanya, Zaynub Ghufoor, Benjamin Forson, Joanne Marks, Havovi Chichger   +5 more
openalex   +2 more sources

Taste Receptor Cells Generate Oscillating Receptor Potentials by Activating G Protein-Coupled Taste Receptors

Frontiers in Physiology, 2022
The receptor potentials of taste receptor cells remain unclear. Here, we demonstrate that taste receptor cells generate oscillating depolarization (n = 7) with action potentials in response to sweet, bitter, umami, and salty taste substances.
Yoshiki Nakao, Katsumi Tateno, Yoshitaka Ohtubo   +2 more
doaj   +3 more sources

Evolutionary insights into umami, sweet, and bitter taste receptors in amphibians [PDF]

Ecology and Evolution, 2021
Umami and sweet sensations provide animals with important dietary information for detecting and consuming nutrients, whereas bitter sensation helps animals avoid potentially toxic or harmful substances. Enormous progress has been made toward animal sweet/
Huaming Zhong, Jie Huang, Shuai Shang, Baodong Yuan   +3 more
doaj   +2 more sources

Sweet taste receptor serves to activate glucose- and leptin-responsive neurons in the hypothalamic arcuate nucleus and participates in glucose responsiveness.

Frontiers in Neuroscience, 2016
The hypothalamic feeding center plays an important role in energy homeostasis. In the feeding center, whole-body energy signals including hormones and nutrients are sensed, processed, and integrated.
Daisuke Kohno, Miho Koike, Yuzo Ninomiya, Itaru Kojima, Tadahiro Kitamura, Toshihiko Yada   +5 more
doaj   +2 more sources

Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2. [PDF]

PLoS ONE, 2015
Although the five basic taste qualities-sweet, sour, bitter, salty and umami-can be recognized by the respective gustatory system, interactions between these taste qualities are often experienced when food is consumed.
Jaewon Shim, Hee Jin Son, Yiseul Kim, Ki Hwa Kim, Jung Tae Kim, Hana Moon, Min Jung Kim, Takumi Misaka, Mee-Ra Rhyu   +8 more
doaj   +2 more sources

Relaxation of selective constraint on the sweet-taste receptor gene TAS1R2 in lorisiform primates. [PDF]

Sci Rep
Ji Q, Hou M, Akhtar MS, Hayakawa T, Toda Y, Itoigawa A, Imai H, Ishida T, Melin AD, Kawamura S.   +9 more
europepmc   +3 more sources

<i>TAS1R2</i>/<i>TAS1R3</i> Single-Nucleotide Polymorphisms Affect Sweet Taste Receptor Activation by Sweeteners: The SWEET Project. [PDF]

Nutrients
Belloir C, Jeannin M, Karolkowski A, Briand L.   +3 more
europepmc   +3 more sources

Bitter Taste Receptor 46 (hTAS2R46) Protects Monocytes/Macrophages from Oxidative Stress [PDF]

Int J Mol Sci
Talmon M, Camillo L, Vietti I, Pollastro F, Fresu L.   +4 more
europepmc   +3 more sources

Taste Receptors beyond Taste Buds

International Journal of Molecular Sciences, 2022
Taste receptors are responsible for detecting their ligands not only in taste receptor cells (TRCs) but also in non-gustatory organs. For several decades, many research groups have accumulated evidence for such “ectopic” expression of taste receptors. More recently, some of the physiologic functions (apart from taste) of these ectopic taste receptors ...
Ki, Su Young, Jeong, Yong Taek
openaire   +2 more sources