Results 111 to 120 of about 2,584,981 (353)

Interactions of SARS-CoV-2 spike protein and transient receptor potential (TRP) cation channels could explain smell, taste, and/or chemesthesis disorders [PDF]

, 2021
Halim Maaroufi
openalex   +1 more source

Taste responses in mice lacking taste receptor subunit T1R1

The Journal of Physiology, 2013
Key points The taste receptor heterodimer T1R1 + T1R3, metabotropic glutamate receptors (mGluRs) and/or their variants may function as umami taste receptors. Here, we used newly developed T1R1−/− mice and examined the role of T1R1 and mGluRs in taste detection.
Yoko, Kusuhara, Ryusuke, Yoshida, Tadahiro, Ohkuri, Keiko, Yasumatsu, Anja, Voigt, Sandra, Hübner, Katsumasa, Maeda, Ulrich, Boehm, Wolfgang, Meyerhof, Yuzo, Ninomiya   +9 more
openaire   +3 more sources

Navigating new norms: a systematic review of factors for the development of effective digital tools in higher education

FEBS Open Bio, EarlyView.
What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman, Jessica Haines, Connie Pritchard, Stephen Rutherford, Nigel Francis   +4 more
wiley   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells [PDF]

, 2015
Pawan Sharma, Alfredo Panebra, Tonio Pera, Brian C. Tiegs, Alena Hershfeld, Lawrence C. Kenyon, Deepak A. Deshpande   +6 more
openalex   +1 more source

Changes of Taste, Smell and Eating Behavior in Patients Undergoing Bariatric Surgery: Associations with PROP Phenotypes and Polymorphisms in the Odorant-Binding Protein OBPIIa and CD36 Receptor Genes [PDF]

, 2021
Melania Melis, Stefano Pintus, Mariano Mastinu, Giovanni Fantola, Roberto Moroni, Marta Yanina Pepino, Iole Tomassini Barbarossa   +6 more
openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

FEBS Open Bio
G protein‐coupled receptors (GPCRs) are responsible for sensing sweet, umami, and bitter tastes. Bitter taste receptors belong to the taste receptor type 2 (TAS2R) family, and although trigeminal stimulants, such as menthol, have been reported to reduce ...
Miyuu Saito, Takumi Misaka
doaj   +1 more source

Immunocytochemical evidence for co-expression of Type III IP₃ receptor with signaling components of bitter taste transduction

BMC Neuroscience, 2001
Background Taste receptor cells are responsible for transducing chemical stimuli into electrical signals that lead to the sense of taste. An important second messenger in taste transduction is IP3, which is involved in both bitter and sweet transduction ...
Kinnamon Sue C, Margolskee Robert F, Stone Leslie M, Clapp Tod R   +3 more
doaj   +1 more source

Functional roles of the sweet taste receptor in oral and extraoral tissues

Current opinion in clinical nutrition and metabolic care, 2014
Purpose of review This review summarizes and discusses the current knowledge about the physiological roles of the sweet taste receptor in oral and extraoral tissues. Recent findings The expression of a functional sweet taste receptor has been reported in
A. Laffitte, F. Neiers, L. Briand
semanticscholar   +1 more source