Results 31 to 40 of about 2,584,981 (353)

Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor

BMC Neuroscience, 2005
Background The sweet taste inhibitor lactisole acts on the human sweet taste receptor heteromer TAS1R2-TAS1R3 but not on its rodent counterpart. Recently, it was shown that the lactisole sensitivity of the human sweet taste receptor involves the part of ...
Meyerhof Wolfgang, Bufe Bernd, Winnig Marcel   +2 more
doaj   +1 more source

Novel gurmarin-like peptides from Gymnema sylvestre and their interactions with the sweet taste receptor T1R2/T1R3. [PDF]

Chem Senses
Maaroufi H.
europepmc   +3 more sources

G Protein-Coupled Receptors in Taste Physiology and Pharmacology

Frontiers in Pharmacology, 2020
Heterotrimeric G protein-coupled receptors (GPCRs) comprise the largest receptor family in mammals and are responsible for the regulation of most physiological functions.
Raise Ahmad, Julie E. Dalziel
doaj   +1 more source

Zebrafish and medaka T1R (taste receptor type 1) proteins mediate highly sensitive recognition of l‐proline

FEBS Open Bio, 2023
In vertebrates, nutritional tastants, such as amino acids and sugars, are recognized by G‐protein‐coupled receptors of the taste receptor type 1 (T1R) family.
Ryusei Goda, Soichi Watanabe, Takumi Misaka   +2 more
doaj   +1 more source

The Role of Cholecystokinin in Peripheral Taste Signaling in Mice

Frontiers in Physiology, 2017
Cholecystokinin (CCK) is a gut hormone released from enteroendocrine cells. CCK functions as an anorexigenic factor by acting on CCK receptors expressed on the vagal afferent nerve and hypothalamus with a synergistic interaction between leptin.
Ryusuke Yoshida, Ryusuke Yoshida, Misa Shin, Misa Shin, Keiko Yasumatsu, Keiko Yasumatsu, Shingo Takai, Mayuko Inoue, Mayuko Inoue, Noriatsu Shigemura, Soichi Takiguchi, Seiji Nakamura, Yuzo Ninomiya, Yuzo Ninomiya, Yuzo Ninomiya   +14 more
doaj   +1 more source

Expression of Galpha14 in sweet-transducing taste cells of the posterior tongue

BMC Neuroscience, 2008
Background "Type II"/Receptor cells express G protein-coupled receptors (GPCRs) for sweet, umami (T1Rs and mGluRs) or bitter (T2Rs), as well as the proteins for downstream signalling cascades.
Kim Soochong, Barrows Jennell K, Dvoryanchikov Gennady, Tizzano Marco, Chaudhari Nirupa, Finger Thomas E   +5 more
doaj   +1 more source

A physiologic role for serotonergic transmission in adult rat taste buds. [PDF]

PLoS ONE, 2014
Of the multiple neurotransmitters and neuropeptides expressed in the mammalian taste bud, serotonin remains both the most studied and least understood.
Luc Jaber, Fang-li Zhao, Tamara Kolli, Scott Herness   +3 more
doaj   +1 more source

TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance It is currently thought that the transduction of bitter, sweet, and umami stimuli in taste cells depends on G protein-coupled receptor signaling with transient receptor potential melastatin 5 (TRPM5) acting as a common downstream component ...
Debarghya Dutta Banik, Laura E Martin, M. Freichel, A. Torregrossa, K. Medler   +4 more
semanticscholar   +1 more source

Metal Ions Activate the Human Taste Receptor TAS2R7

Chemical Sensors, 2019
Divalent and trivalent salts exhibit a complex taste profile. They are perceived as being astringent/drying, sour, bitter, and metallic. We hypothesized that human bitter-taste receptors may mediate some taste attributes of these salts.
Yi Wang, Amanda L Zajac, Weiwei Lei, C. Christensen, R. Margolskee, Cédric Bouysset, J. Golebiowski, Huabin Zhao, S. Fiorucci, Peihua Jiang   +9 more
semanticscholar   +1 more source

Tachykinins stimulate a subset of mouse taste cells. [PDF]

PLoS ONE, 2012
The tachykinins substance P (SP) and neurokinin A (NKA) are present in nociceptive sensory fibers expressing transient receptor potential cation channel, subfamily V, member 1 (TRPV1).
Jeff Grant
doaj   +1 more source