Results 71 to 80 of about 2,584,981 (353)

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Exploring the taste presentation and receptor perception mechanism of salty peptides from Stropharia rugosoannulata based on molecular dynamics and thermodynamics simulation

Food Science and Human Wellness
The taste presentation and receptor perception mechanism of the salty peptide of Stropharia rugosoannulata were predicted and verified using peptide omics and molecular interaction techniques.
Wen Li, Shuai Sun, Wanchao Chen, Haile Ma, Tingzhao Li, Zhong Zhang, Di Wu, Mengqiu Yan, Yan Yang   +8 more
doaj   +1 more source

The Origin of Unpleasant Aftertastes in Synthetic Sweeteners: A Hypothesis

Frontiers in Molecular Biosciences, 2019
Most sweeteners are plagued with unwanted unpleasant aftertastes. Here we examined the possibility that one of the main reasons for this is the similarity of sweet and umami receptors.
Waldo Acevedo, Piero A. Temussi, Piero A. Temussi   +2 more
doaj   +1 more source

Impact of obesity on taste receptor expression in extra-oral tissues: emphasis on hypothalamus and brainstem

Scientific Reports, 2016
Sweet perception promotes food intake, whereas that of bitterness is inhibitory. Surprisingly, the expression of sweet G protein-coupled taste receptor (GPCTR) subunits (T1R2 and T1R3) and bitter GPCTRs (T2R116, T2R118, T2R138 and T2R104), as well as the
D. Herrera Moro Chao, C. Argmann, M. van Eijk, R. Boot, R. Ottenhoff, C. V. van Roomen, E. Foppen, J. Siljee, U. A. Unmehopa, A. Kalsbeek, J. M. F. G. Aerts   +10 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Expansion of a bitter taste receptor family in a polyphagous insect herbivore

Scientific Reports, 2016
The Insect taste system plays a central role in feeding behaviours and co-evolution of insect-host interactions. Gustatory receptors form the interface between the insect taste system and the environment.
W. Xu, A. Papanicolaou, Hui-Jie Zhang, A. Anderson   +3 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Ric-8A, a Gα protein guanine nucleotide exchange factor potentiates taste receptor signaling

Frontiers in Cellular Neuroscience, 2009
Taste receptors for sweet, bitter and umami tastants are G-protein coupled receptors (GPCRs). While much effort has been devoted to understanding G-protein-receptor interactions and identifying the components of the signalling cascade downstream of these
Claire J Fenech, lila Patrikainen, Daniel S Kerr, Sylvie Grall, Zhenhui Liu, Fabienne Laugerette, Bettina Malnic, Jean-Pierre Montmayeur, Jean-Pierre Montmayeur   +8 more
doaj   +1 more source

Glutamate may be an efferent transmitter that elicits inhibition in mouse taste buds. [PDF]

PLoS ONE, 2012
Recent studies suggest that l-glutamate may be an efferent transmitter released from axons innervating taste buds. In this report, we determined the types of ionotropic synaptic glutamate receptors present on taste cells and that underlie this postulated
Yijen A Huang, Jeff Grant, Stephen Roper
doaj   +1 more source

Synergism, Bifunctionality, and the Evolution of a Gradual Sensory Trade-off in Hummingbird Taste Receptors [PDF]

, 2021
Glenn Cockburn, Meng‐Ching Ko, Keren R. Sadanandan, Eliot T. Miller, Tomoya Nakagita, Amanda Monte, Sungbo Cho, E. Roura, Yasuka Toda, Maude W. Baldwin   +9 more
openalex   +1 more source