Results 81 to 90 of about 2,584,981 (353)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Shrinkage of ipsilateral taste buds and hyperplasia of contralateral taste buds following chorda tympani nerve transection

Neural Regeneration Research, 2015
The morphological changes that occur in the taste buds after denervation are not well understood in rats, especially in the contralateral tongue epithelium.
Yi-ke Li, Juan-mei Yang, Yi-bo Huang, Dong-dong Ren, Fang-lu Chi   +4 more
doaj   +1 more source

Functional dissociation in sweet taste receptor neurons between and within taste organs of Drosophila

Nature Communications, 2016
Finding food sources is essential for survival. Insects detect nutrients with external taste receptor neurons. Drosophila possesses multiple taste organs that are distributed throughout its body.
Vladimiros Thoma, S. Knapek, S. Arai, Marion Hartl, H. Kohsaka, Pudith Sirigrivatanawong, Ayako Abe, K. Hashimoto, Hiromu Tanimoto   +8 more
semanticscholar   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Genetic Variation in the TAS2R38 Bitter Taste Receptor and Smoking Behaviors

PLoS ONE, 2016
Common TAS2R38 taste receptor gene variants specify the ability to taste phenylthiocarbamide (PTC), 6-n-propylthiouracil (PROP) and structurally related compounds.
D. Risso, J. Kozlitina, E. Sainz, Joanne Gutierrez, S. Wooding, Betelihem Getachew, D. Luiselli, C. Berg, D. Drayna   +8 more
semanticscholar   +1 more source

Acetylcholine and Acetylcholine Receptors in Taste Receptor Cells [PDF]

Chemical Senses, 2005
Neuroactive substances play important roles as transmitters and neuromodulators. Although many of these substances and/or their receptors are known to be present in taste receptor cells and nerve fibers innervating taste buds, physiological functions of these substances are not well understood (Nagai et al., 1996).
Tatsuya, Ogura, Weihong, Lin
openaire   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The role of bitter and sweet taste receptors in upper airway innate immunity: Recent advances and future directions

World Journal of Otorhinolaryngology-Head and Neck Surgery, 2018
Bitter (T2R) and sweet (T1R) taste receptors have been implicated in sinonasal innate immunity and in the pathophysiology of chronic rhinosinusitis (CRS).
Ivy W. Maina, Alan D. Workman, Noam A. Cohen   +2 more
doaj   +1 more source

Expression and Functional Activity of the Human Bitter Taste Receptor TAS2R38 in Human Placental Tissues and JEG-3 Cells

Molecules, 2016
Bitter taste receptors (TAS2Rs) are expressed in mucous epithelial cells of the tongue but also outside the gustatory system in epithelial cells of the colon, stomach and bladder, in the upper respiratory tract, in the cornified squamous epithelium of ...
U. Wölfle, F. Elsholz, A. Kersten, Birgit Haarhaus, U. Schumacher, C. Schempp   +5 more
semanticscholar   +1 more source

Drosophila sweet taste receptor [PDF]

Pure and Applied Chemistry, 2002
Abstract Like the Sac locus controlling sugar sensitivity in mice, the taste gene Tre of the fruitfly Drosophila was discovered in wild populations as a genetic dimorphism controlling gustatory sensitivity to a sugar trehalose. By activating a P-element transposon near the gene locus we obtained induced Tre mutations and analyzed the ...
Kunio Isono, Kohei Ueno, Masayuki Ohta, Hiromi Morita   +3 more
openaire   +1 more source