Results 21 to 30 of about 1,021,795 (377)
Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases [PDF]
Journal of Neurochemistry, 2009 AbstractTau is a neuronal microtubule‐associated protein. Its hyperphosphorylation plays a critical role in Alzheimer disease (AD). Expression and phosphorylation of tau are regulated developmentally, but its dynamic regulation and the responsible kinases or phosphatases remain elusive.
Yi Li +11 more
openaire +3 more sources
Cytoskeleton, 2023 AbstractFirst identified in 1975, tau was implicated in Alzheimer's disease 10 years later. Filamentous tangle inclusions were known to be made of hyperphosphorylated tau by 1991, with similar inclusions gaining recognition for being associated with other neurodegenerative diseases. In 1998, mutations in MAPT, the gene that encodes tau, were identified
Goedert, Michel +3 more
openaire +2 more sources
Cost Effectiveness and Resource Allocation, 2020 Background Diabetic retinopathy (DR) is a significant global public health and economic burden. DR accounts for approximately 15–17% of all cases of total blindness in the USA and Europe.
Daniel Avidor +3 more
doaj +1 more source
EAI Endorsed Transactions on Context-aware Systems and Applications, 2017 In this paper we propose novel context-aware algorithms for hand poses classifying on images and video-sequences. The proposed hand poses classifying on images algorithm based on Viola-Jones method, wavelet transform, PCA and neural networks.
Phan Ngoc Hoang, Bui Thi Thu Trang
doaj +1 more source
Tau Aggregates and Tau Pathology
Journal of Alzheimer's Disease, 2008 There is controversy in some neurodegenerative disorders whether the presence of aberrant aggregates in a neuron could have a toxic or a protective effect. In some disorders like in encephalopathies (prion disease), protein aggregates are toxic for the neuron.
Hernández, Félix, Ávila, Jesús
openaire +4 more sources
Acetyl-L-carnitine flux to lipids in cells estimated using isotopomer spectral analysis
Journal of Lipid Research, 1997 Acetyl-L-carnitine is known as a reservoir of activated acetyl units and as a modulator of metabolic function. The objective of this study was to quantify the fate of the acetyl moiety of acetyl-L-carnitine in lipogenic pathways.
L Lligona-Trulla +4 more
doaj +1 more source
Nature Communications, 2020 The αvβ6 integrin is key in activating the pro-fibrotic cytokine TGFβ in idiopathic pulmonary fibrosis. Here, the authors show an inhaled small molecule αvβ6 inhibitor GSK3008348 induces prolonged inhibition of TGFβ signaling pathways in human and murine
Alison E. John +36 more
doaj +1 more source
Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration
Journal of Experimental Medicine, 2022 Tau present in the extracellular fluids has a critical role in the pathogenesis of tauopathies. The authors describe that glymphatic clearance of extracellular tau impacts tau accumulation and neurodegeneration.
K. Ishida +7 more
semanticscholar +1 more source
Lepton and Photon Interactions at High Energies, 1992 16 pages, 8 figures. Invited talk at the XIX International Symposium on Lepton and Photon Interactions at High Energies (Stanford, August 1999)
openaire +6 more sources
Tau Pathology Generated by Overexpression of Tau [PDF]
The American Journal of Pathology, 1999 Neurofibrillary changes of abnormally hyperphosphorylated tau are the key lesion in Alzheimer’s disease (AD) and a number of other tauopathies. Recent developments in the field of autosomal dominantly inherited dementias, in particular the frontotemporal dementias and Parkinsonism linked to chromosome 17 (FTDP-17) group, have shown that abnormalities ...
Khalid Iqbal, Inge Grundke-Iqbal
openaire +3 more sources