Results 101 to 110 of about 5,915,409 (225)
Defining the organizational structure of dopamine and muscarninic acetylcholine receptors [PDF]
, 2015 No abstract ...
Alvarez-Curto, Elisa +4 more
core +1 more source
BiomedicinesBackground: Parkinson’s disease (PD) is characterized not only by motor dysfunction but also by widespread degeneration across cortico-striatal, limbic, and cortical circuits.
João Paulo Mota Telles +3 more
doaj +1 more source
Structure-based inhibitors of amyloid beta core suggest a common interface with tau. [PDF]
, 2019 Alzheimer's disease (AD) pathology is characterized by plaques of amyloid beta (Aβ) and neurofibrillary tangles of tau. Aβ aggregation is thought to occur at early stages of the disease, and ultimately gives way to the formation of tau tangles which ...
Bowler, Jeannette +13 more
core +1 more source
A Novel Genetic Screen Identifies Modifiers of Age-Dependent Amyloid β Toxicity in the Drosophila Brain [PDF]
, 2017 The accumulation of amyloid β peptide (Aβ) in the brain of Alzheimer's disease (AD) patients begins many years before clinical onset. Such process has been proposed to be pathogenic through the toxicity of Aβ soluble oligomers leading to synaptic ...
Belfiori Carrasco, Lautaro Francisco +5 more
core +1 more source
Application of PET imaging in the diagnosis and prognosis prediction of autoimmune encephalitis
Chinese Journal of Contemporary Neurology and NeurosurgeryPET imaging plays a crucial role in the diagnosis and management of autoimmune encephalitis (AE). By detecting the distribution of radiotracers, PET provides a direct visualization of cerebral metabolic activity, revealing distinct metabolic patterns ...
WANG Ning, SUN Yue-qian, WANG Qun
doaj +1 more source
Toxic Tau Oligomers Modulated by Novel Curcumin Derivatives [PDF]
, 2019 The pathological aggregation and accumulation of tau, a microtubule-associated protein, is a common feature amongst more than 18 different neurodegenerative diseases that are collectively known as tauopathies.
Bucchieri, Fabio +6 more
core +1 more source
Effects of an OX2R agonist on migration and removal of tau from mouse brain
Scientific ReportsPathological proteins including tau are produced in neurons and released into interstitial fluid (ISF) in a neural activity-dependent manner during wakefulness.
Michiko Terada +4 more
doaj +1 more source
Human cyclophilin 40 unravels neurotoxic amyloids.
PLoS Biology, 2017 The accumulation of amyloidogenic proteins is a pathological hallmark of neurodegenerative disorders. The aberrant accumulation of the microtubule associating protein tau (MAPT, tau) into toxic oligomers and amyloid deposits is a primary pathology in ...
Jeremy D Baker +18 more
doaj +1 more source
Journal of Experimental Neuroscience, 2019 A mechanism that describes the progression of traumatic brain injury (TBI) to end-stage chronic traumatic encephalopathy (CTE) is offered in this article.
Melissa Demock, Steven Kornguth
doaj +1 more source
Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH. [PDF]
, 2019 Tau, a member of the MAP2/tau family of microtubule-associated proteins, stabilizes and organizes axonal microtubules in healthy neurons. In neurodegenerative tauopathies, tau dissociates from microtubules and forms neurotoxic extracellular aggregates ...
Barber, Diane L +7 more
core