Results 171 to 180 of about 5,828,673 (370)

Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity

Advanced Materials, EarlyView.
This study introduces glutathione‐stabilized gold nanoparticles for targeted lithium delivery (LiG‐AuNPs), enabling the controlled modulation of Glycogen Synthase Kinase‐3 (GSK‐3β). These non‐toxic, 2‐nm particles release lithium intracellularly, effectively inhibiting GSK‐3β in the brain without significant plasma lithium alterations.
Antonio Buonerba, Giulia Puliatti, Domenica Donatella Li Puma, Bruno Bandiera, Beatrice Cannata, Maria Elena Marcocci, Nicolina Castagno, Irene Contento, Salvatore Impemba, Mariarosa Scognamiglio, Rocco Di Girolamo, Vincenzo Naddeo, Patrizia Canton, Carmine Capacchione, Laura Sposito, Martina Albini, Francesco Pastore, Silvia Baroni, Alfonso Grassi, Claudio Grassi, Roberto Piacentini   +20 more
wiley   +1 more source

Plasma tau proteins for the diagnosis of mild cognitive impairment and Alzheimer's disease: A systematic review and meta-analysis. [PDF]

Front Aging Neurosci, 2022
Chen L, Niu X, Wang Y, Lv S, Zhou X, Yang Z, Peng D.   +6 more
europepmc   +1 more source

Vertical Nanostructures as Novel Interfaces for Brain Research

Advanced Materials Interfaces, EarlyView.
This review highlights the unique features of vertical nanostructures (nanoneedles, nanostraws, nanopillars, and nanowires) for applications in brain research. Various characteristics of nanostructures, including material selection, fabrication methodology, and geometric designs, are discussed for their specific use in neurite guidance, neuron pinning,
Hao Nguyen Tran, Andrea J. O'Connor, Chennupati Jagadish, Vini Gautam   +3 more
wiley   +1 more source

Tau protein in Alzheimer’s disease.

Current Alzheimer research, 2011
1
openaire   +5 more sources

14-3-3 proteins—a moonlight protein complex with therapeutic potential in neurological disorder: in-depth review with Alzheimer’s disease

Frontiers in Molecular Biosciences
Alzheimer’s disease (AD) affects millions of people worldwide and is a gradually worsening neurodegenerative condition. The accumulation of abnormal proteins, such as tau and beta-amyloid, in the brain is a hallmark of AD pathology.
Gholamareza Abdi, Mukul Jain, Mukul Jain, Nil Patil, Nil Patil, Bindiya Upadhyay, Nigam Vyas, Nigam Vyas, Manish Dwivedi, Radhey Shyam Kaushal, Radhey Shyam Kaushal   +10 more
doaj   +1 more source

Tripartite Relationship Among Synaptic, Amyloid, and Tau Proteins: An In Vivo and Postmortem Study. [PDF]

Neurology, 2021
Casaletto KB, Zetterberg H, Blennow K, Brinkmalm A, Honer W, Schneider JA, Bennett DA, Djukic N, You M, Weiner-Light S, Fonseca C, Miller BL, Kramer J.   +12 more
europepmc   +1 more source

Phosphorylation of microtubule‐associated protein tau by stress‐activated protein kinases [PDF]

, 1997
Michel Goedert, Masato Hasegawa, Ross Jakes, Sean E. Lawler, Ana Cuenda, Philip Cohen   +5 more
openalex   +1 more source

Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation. [PDF]

, 2019
Molecular tweezers (MTs) are supramolecular host molecules equipped with two aromatic pincers linked together by a spacer (Gakh, 2018). They are endowed with fascinating properties originating from their ability to hold guests between their aromatic ...
Bitan, Gal, Hadrovic, Inesa, Klärner, Frank-Gerrit, Rebmann, Philipp, Schrader, Thomas   +4 more
core  

Characterization of The Electrical and Optical Properties of Ultrabithorax Fusion Fibers for Biosensing

Advanced Materials Technologies, EarlyView.
In this work, Ultrabithorax (Ubx) protein fusions with myoglobin, EGFP and mCherry are investigated and proposed for biosensing applications. For the first time, FRET calculations based on fluorescent lifetime measurements are presented for Ubx‐based protein fusions.
Karol Szuba‐Jablonski, A. Bernardus Mostert, Drew B. Riley, Kenith E. Meissner   +3 more
wiley   +1 more source

Insulin Signaling Disruption and INF-γ Upregulation Induce Aβ_1-42 and Hyperphosphorylated-Tau Proteins Synthesis and Cell Death after Paraquat Treatment of Primary Hippocampal Cells. [PDF]

Chem Res Toxicol, 2022
Abascal ML, Sanjuan J, Moyano P, Sola E, Flores A, Garcia JM, Garcia J, Frejo MT, Del Pino J.   +8 more
europepmc   +1 more source