Results 51 to 60 of about 5,828,673 (370)

TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Phase separation of proteins is increasingly thought to play a fundamental role in biological processes. Recent studies show that tau protein phase separates, but the biological significance is unknown since artificial crowding agents are ...
Peter E. A. Ash, Shuwen Lei, Jenifer E. Shattuck, Samantha Boudeau, Y. Carlomagno, Maria Medalla, Bryce L. Mashimo, Guillermo Socorro, Louloua F A Al-Mohanna, Lulu Jiang, Muhammet M. Öztürk, Mark Knobel, P. Ivanov, L. Petrucelli, Susanne Wegmann, N. Kanaan, B. Wolozin   +16 more
semanticscholar   +1 more source

The two shapes of the Tau protein [PDF]

eLife, 2018
Tau proteins can convert from an inert shape to a misfolded shape that seeds the growth of fibers that contribute to the pathology of Alzheimer’s disease.
openaire   +3 more sources

The regulatory effect of Tau protein on polymerization of MCF7 microtubules in vitro

Biochemistry and Biophysics Reports, 2019
Growing evidence continues to point toward the critical role of beta tubulin isotypes in regulating some intracellular functions. Changes that were observed in the microtubules’ intrinsic dynamics, the way they interact with some chemotherapeutic agents,
Mitra Shojania Feizabadi, Marcos A.V. Hernandez, Jane B. Breslin, Ibukunoluwa I. Akintola   +3 more
doaj   +1 more source

Comparison of Common and Disease-Specific Post-translational Modifications of Pathological Tau Associated With a Wide Range of Tauopathies

Frontiers in Neuroscience, 2020
Tauopathies are the most common type of neurodegenerative proteinopathy, being characterized by cytoplasmic aggregates of hyperphosphorylated tau protein. The formation and morphologies of these tau inclusions, the distribution of the lesions and related
Fuyuki Kametani, Mari Yoshida, Tomoyasu Matsubara, Shigeo Murayama, Yuko Saito, Ito Kawakami, Mitsumoto Onaya, Hidetomo Tanaka, Akiyoshi Kakita, Andrew C. Robinson, David M. A. Mann, Masato Hasegawa   +11 more
doaj   +1 more source

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome [PDF]

, 2018
Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles.
Arena, Andrea, Barone, Eugenio, Blarzino, Carla, Butterfield, D. Allan, Di Domenico, Fabio, Lanzillotta, Chiara, Mosca, Luciana, Perluigi, Marzia, Tramutola, Antonella, Zuliani, Ilaria   +9 more
core   +3 more sources

Alzheimer disease pathology and the cerebrospinal fluid proteome

Alzheimer’s Research & Therapy, 2018
Background Altered proteome profiles have been reported in both postmortem brain tissues and body fluids of subjects with Alzheimer disease (AD), but their broad relationships with AD pathology, amyloid pathology, and tau-related neurodegeneration have ...
Loïc Dayon, Antonio Núñez Galindo, Jérôme Wojcik, Ornella Cominetti, John Corthésy, Aikaterini Oikonomidi, Hugues Henry, Martin Kussmann, Eugenia Migliavacca, India Severin, Gene L. Bowman, Julius Popp   +11 more
doaj   +1 more source

Differences Between Human and Murine Tau at the N-terminal End

Frontiers in Aging Neuroscience, 2020
Human tauopathies, such as Alzheimer’s disease (AD), have been widely studied in transgenic mice overexpressing human tau in the brain. The longest brain isoforms of Tau in mice and humans show 89% amino acid identity; however, the expression of the ...
Félix Hernández, Félix Hernández, Jesús Merchán-Rubira, Laura Vallés-Saiz, Alberto Rodríguez-Matellán, Jesús Avila, Jesús Avila   +6 more
doaj   +1 more source

Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation. [PDF]

PLoS ONE, 2012
Abnormal hyperphosphorylation of microtubule-associated protein tau plays a crucial role in neurodegeneration in Alzheimer's disease (AD). The aggregation of hyperphosphorylated tau into neurofibrillary tangles is also a hallmark brain lesion of AD.
Yang Yu, Lan Zhang, Xiaojing Li, Xiaoqin Run, Zhihou Liang, Yi Li, Ying Liu, Moon H Lee, Inge Grundke-Iqbal, Khalid Iqbal, David J Vocadlo, Fei Liu, Cheng-Xin Gong   +12 more
doaj   +1 more source

The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]

, 2013
Frontotemporal lobar degeneration (FTLD) consists of a group of neurodegenerative diseases characterized by behavioural and executive impairment, language disorders and motor dysfunction.
Calo, Laura, Goedert, Michel, Holton, Janice L., Iovino, Mariangela, Lashley, Tammaryn, Lund University., Lund University., Lund University., Muqit, Miratul M. K., Parmar, Malin,, Pfisterer, Ulrich,, Revesz, Tamas, Spillantini, Maria Grazia, Swingler, Robert J., Treacy, Rebecca   +14 more
core   +4 more sources

Liquid-liquid phase separation induces pathogenic tau conformations in vitro

Nature Communications, 2020
Formation of membrane-less organelles via liquid-liquid phase separation is one way cells meet the biological requirement for spatiotemporal regulation of cellular components and reactions.
N. Kanaan, Chelsey Hamel, Tessa Grabinski, Benjamin Combs   +3 more
semanticscholar   +1 more source