Results 61 to 70 of about 5,909,902 (374)

SUMO1 modification of 0N4R-tau is regulated by PIASx, SENP1, SENP2, and TRIM11

Biochemistry and Biophysics Reports
Tau is a microtubule-associated protein that contributes to cytoskeletal stabilization. Aggregation of tau proteins is associated with neurodegenerative disorders such as Alzheimer's disease.
Harmony Wada, Takuma Maruyama, Takako Niikura   +2 more
doaj   +1 more source

Pressure Effects in Supercooled Water: Comparison between a 2D Model of Water and Experiments for Surface Water on a Protein

, 2008
Experiments in bulk water confirm the existence of two local arrangements of water molecules with different densities, but, because of inevitable freezing at low temperature $T$, can not ascertain whether the two arrangements separate in two phases.
Chen, Sow-Hsin, Chu, Xiang-qiang, Franzese, Giancarlo, Kumar, Pradeep, Mazza, Marco G., Stanley, H. Eugene, Stokely, Kevin   +6 more
core   +1 more source

Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects

Frontiers in Aging Neuroscience, 2019
Microtubules (MTs) play a fundamental role in many vital processes such as cell division and neuronal activity. They are key structural and functional elements in axons, supporting neurite differentiation and growth, as well as transporting motor ...
P. Barbier, Orgeta Zejneli, M. Martinho, Alessia Lasorsa, V. Belle, Caroline Smet-Nocca, P. Tsvetkov, F. Devred, I. Landrieu   +8 more
semanticscholar   +1 more source

Improved Expression of Aggregation-Prone Tau Proteins Using a Spidroin-Derived Solubility Tag

Separations
Tauopathies, a group of neurodegenerative disorders, are characterized by the abnormal aggregation of microtubule-associated Tau proteins in neurons and glial cells.
Kevin Muwonge, Bedri Yaman, Attila Mészáros, Giorgio Russo, Alexander Volkov, Peter Tompa   +5 more
doaj   +1 more source

Different Amyloid-β Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation. [PDF]

, 2019
Alzheimer's disease (AD) pathology is characterized by the aggregation of beta-amyloid (Aβ) and tau in the form of amyloid plaques and neurofibrillary tangles in the brain.
Bitan, Gal, Di, Jing, Jiang, Lin, Li, Binsen, Murray, Kevin A, Shin, Woo Shik, Sun, Chuanqi   +6 more
core  

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in alzheimer’s disease and parkinson’s disease [PDF]

, 2017
Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and mortality.
Chakrabarti, S., Chatterjee, U., Ganguly, G., Saso, L.   +3 more
core   +3 more sources

ALZHEIMER'S DISEASE AND TAU PROTEINS

The Lancet, 1986
info:eu-repo/semantics ...
Brion, Jean Pierre, Flament Durand, Jacqueline, Dustin, Pierre   +2 more
openaire   +3 more sources

Tau Protein: Function and Pathology [PDF]

International Journal of Alzheimer's Disease, 2012
In the last decade, the fundamental role of the microtubule-associated protein tau in neurodegeneration and dementia has been widely accepted. The generation of various transgenic models for tau pathology, varying in expressed mutations and driving promoters with either permanent (constitutive) or inducible expression, as well as the use of alternative
Rosenmann, Hanna, Blum, David, Kayed, Rakez, Ittner, Lars M.   +3 more
openaire   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Interactions and Cytotoxicity of Human Neurodegeneration- Associated Proteins Tau and α-Synuclein in the Simple Model Dictyostelium discoideum

Frontiers in Cell and Developmental Biology, 2021
The abnormal accumulation of the tau protein into aggregates is a hallmark in neurodegenerative diseases collectively known as tauopathies. In normal conditions, tau binds off and on microtubules aiding in their assembly and stability dependent on the ...
Katelyn Mroczek, Sanjanie Fernando, Paul R. Fisher, Sarah J. Annesley   +3 more
doaj   +1 more source