Results 71 to 80 of about 5,828,673 (370)

Improved Expression of Aggregation-Prone Tau Proteins Using a Spidroin-Derived Solubility Tag

Separations
Tauopathies, a group of neurodegenerative disorders, are characterized by the abnormal aggregation of microtubule-associated Tau proteins in neurons and glial cells.
Kevin Muwonge, Bedri Yaman, Attila Mészáros, Giorgio Russo, Alexander Volkov, Peter Tompa   +5 more
doaj   +1 more source

Different Amyloid-β Self-Assemblies Have Distinct Effects on Intracellular Tau Aggregation. [PDF]

, 2019
Alzheimer's disease (AD) pathology is characterized by the aggregation of beta-amyloid (Aβ) and tau in the form of amyloid plaques and neurofibrillary tangles in the brain.
Bitan, Gal, Di, Jing, Jiang, Lin, Li, Binsen, Murray, Kevin A, Shin, Woo Shik, Sun, Chuanqi   +6 more
core  

Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies [PDF]

, 2010
Preprin
Harrington, Charles R, Storey, John M D, Wischik, Claude M, Wischik, Damon J   +3 more
core   +1 more source

Role of Tau as a Microtubule-Associated Protein: Structural and Functional Aspects

Frontiers in Aging Neuroscience, 2019
Microtubules (MTs) play a fundamental role in many vital processes such as cell division and neuronal activity. They are key structural and functional elements in axons, supporting neurite differentiation and growth, as well as transporting motor ...
P. Barbier, Orgeta Zejneli, M. Martinho, Alessia Lasorsa, V. Belle, Caroline Smet-Nocca, P. Tsvetkov, F. Devred, I. Landrieu   +8 more
semanticscholar   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Alterations in iron content, iron-regulatory proteins and behaviour without tau pathology at one year following repetitive mild traumatic brain injury

Acta Neuropathologica Communications, 2023
Repetitive mild traumatic brain injury (r-mTBI) has increasingly become recognised as a risk factor for the development of neurodegenerative diseases, many of which are characterised by tau pathology, metal dyshomeostasis and behavioural impairments.
Sydney M. A. Juan, Maria Daglas, Phan H. Truong, Celeste Mawal, Paul A. Adlard   +4 more
doaj   +1 more source

Spreading of P301S Aggregated Tau Investigated in Organotypic Mouse Brain Slice Cultures

Biomolecules, 2022
Tau pathology extends throughout the brain in a prion-like fashion through connected brain regions. However, the details of the underlying mechanisms are incompletely understood.
Dhwani S. Korde, Christian Humpel
doaj   +1 more source

Pressure Effects in Supercooled Water: Comparison between a 2D Model of Water and Experiments for Surface Water on a Protein

, 2008
Experiments in bulk water confirm the existence of two local arrangements of water molecules with different densities, but, because of inevitable freezing at low temperature $T$, can not ascertain whether the two arrangements separate in two phases.
Chen, Sow-Hsin, Chu, Xiang-qiang, Franzese, Giancarlo, Kumar, Pradeep, Mazza, Marco G., Stanley, H. Eugene, Stokely, Kevin   +6 more
core   +1 more source

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients. [PDF]

, 2015
Quantification of disease-associated proteins in the cerebrospinal fluid (CSF) has been critical for the study and treatment of several neurodegenerative disorders; however, mutant huntingtin protein (mHTT), the cause of Huntington's disease (HD), is at ...
Andreas Weiss, Benjamini, Blair R. Leavitt, Douglas Langbehn, Douglas Macdonald, Edward J. Wild, Henrik Zetterberg, James R.C. Miller, Jeromin, Ko, Lewczuk, Nicola Robertson, Rainer Kuhn, Roberto Boggio, Rosengren, Salman Haider, Sarah J. Tabrizi   +16 more
core   +1 more source

Amyloid Beta and Phosphorylated Tau-Induced Defective Autophagy and Mitophagy in Alzheimer’s Disease

Cells, 2019
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by memory loss and multiple cognitive impairments. Several decades of intense research have revealed that multiple cellular changes are implicated in the development and ...
P. Hemachandra Reddy, D. Oliver
semanticscholar   +1 more source