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Frontotemporal dementia and tauopathy
Current Neurology and Neuroscience Reports, 2001The presence of abundant neurofibrillary lesions made of hyperphosphorylated tau proteins is the characteristic neuropathology of a subset of neurodegenerative disorders classified as "tauopathies." The discovery of mutations in the tau gene in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) constitutes convincing evidence ...
Y, Yoshiyama, V M, Lee, J Q, Trojanowski
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Treatment Options for Tauopathies
Current Treatment Options in Neurology, 2012To date, there are no approved and established pharmacologic treatment options for tauopathies, a very heterogenous group of neuropsychiatric diseases often leading to dementia and clinically diagnosed as atypical Parkinson syndromes. Among these so-called Parkinson plus syndromes are progressive supranuclear palsy (PSP), also referred to as Steele ...
Tarik, Karakaya +3 more
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Pathogenesis of the Tauopathies
Journal of Molecular Neuroscience, 2011Microtubule-associated protein tau is the most commonly misfolded protein in human neurodegenerative diseases, where it becomes hyperphosphorylated and filamentous. Mutations in MAPT, the tau gene, cause approximately 5% of cases of frontotemporal dementia. They are frequently accompanied by parkinsonism. The existence of MAPT mutations has established
Michel, Goedert +1 more
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Neuropathology of familial tauopathy
Neuropathology, 2006Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP‐17) is a hereditary progressive neurodegenerative disorder. FTDP‐17 was originally defined in Ann Arbor, Michigan, in 1996. Since then, more than 100 families with FTDP‐17 have been described throughout the world, including 18 families identified in Japan.
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New classification of tauopathies
Revue Neurologique, 2018Tauopathies are a group of neurodegenerative diseases characterized by pathological intracellular deposits of the protein tau. Isoform composition, morphology and anatomical distribution of cellular tau-immunoreactivities are defining distinct tauopathies as molecular pathological disease entities.
Höglinger, G. U. +2 more
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X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women
Cell, 2022Yeo Jung Koh, David E. Kang
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Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains
Cell, 2020Yari Carlomagno +2 more
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