Results 211 to 220 of about 22,537 (257)
International Journal of Molecular Sciences, 2021 Tauopathy refers to a group of progressive neurodegenerative diseases, including frontotemporal lobar degeneration and Alzheimer’s disease, which correlate with the malfunction of microtubule-associated protein Tau (MAPT) due to abnormal ...
Manivannan Subramanian +2 more
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Broad activation of the Parkin pathway induces synaptic mitochondrial deficits in early tauopathy [PDF]
Brain, 2022 Mitochondrial defects are a hallmark of early pathophysiology in Alzheimer’s disease, with pathologically phosphorylated tau reported to induce mitochondrial toxicity.
Yu Young Jeong +2 more
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Crosstalk between Oxidative Stress and Tauopathy
International Journal of Molecular Sciences, 2019 Tauopathy is a collective term for neurodegenerative diseases associated with pathological modifications of tau protein. Tau modifications are mediated by many factors.
Md Mamunul Haque +2 more
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Cognitive trajectory in mild cognitive impairment due to primary age-related tauopathy
Brain, 2020 Teylan et al. reveal slower cognitive decline in primary age-related tauopathy (PART) than in Alzheimer’s disease across multiple neuropsychological domains, lending further support to the hypothesis that PART has distinct clinical features compared to ...
Merilee Teylan +2 more
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Tau Fibril Formation in Cultured Cells Compatible with a Mouse Model of Tauopathy [PDF]
International Journal of Molecular Sciences, 2018 Neurofibrillary tangles composed of hyperphosphorylated tau protein are primarily neuropathological features of a number of neurodegenerative diseases collectively termed tauopathy.
, Taeko Kimura, Tetsuya Suhara
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Current Opinion in Neurology, 2017
Purpose of review The purpose of this review is to provide an update on the role of tau beyond the stabilization of microtubules and on the clinical, pathological, diagnostic and therapeutic aspects of tauopathies. Recent findings Beyond its function as a microtubule-associated tau ...
Thibaud, Lebouvier +2 more
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Purpose of review The purpose of this review is to provide an update on the role of tau beyond the stabilization of microtubules and on the clinical, pathological, diagnostic and therapeutic aspects of tauopathies. Recent findings Beyond its function as a microtubule-associated tau ...
Thibaud, Lebouvier +2 more
openaire +2 more sources
2023
Tauopathies are a clinically and neuropathologically heterogeneous group of neurodegenerative disorders, characterized by abnormal tau aggregates. Tau, a microtubule-associated protein, is important for cytoskeletal structure and intracellular transport.
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Tauopathies are a clinically and neuropathologically heterogeneous group of neurodegenerative disorders, characterized by abnormal tau aggregates. Tau, a microtubule-associated protein, is important for cytoskeletal structure and intracellular transport.
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Annual Review of Neuroscience, 2001
▪ Abstract The defining neuropathological characteristics of Alzheimer's disease are abundant filamentous tau lesions and deposits of fibrillar amyloid β peptides. Prominent filamentous tau inclusions and brain degeneration in the absence of β-amyloid deposits are also hallmarks of neurodegenerative tauopathies exemplified by sporadic corticobasal ...
V M, Lee, M, Goedert, J Q, Trojanowski
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▪ Abstract The defining neuropathological characteristics of Alzheimer's disease are abundant filamentous tau lesions and deposits of fibrillar amyloid β peptides. Prominent filamentous tau inclusions and brain degeneration in the absence of β-amyloid deposits are also hallmarks of neurodegenerative tauopathies exemplified by sporadic corticobasal ...
V M, Lee, M, Goedert, J Q, Trojanowski
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Neurology India, 2007
Tau protein is a neuronal microtubule-associated protein (MAP), which localizes primarily in the axon. It is one of the major and most widely distributed MAPs in the central nervous system. Its biochemistry and molecular pathology is being increasingly studied. Tau is a key component of neurofbrillary tangles in Alzheimer's disease (AD). Disorders with
Mathuranath, PS, Robert, M
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Tau protein is a neuronal microtubule-associated protein (MAP), which localizes primarily in the axon. It is one of the major and most widely distributed MAPs in the central nervous system. Its biochemistry and molecular pathology is being increasingly studied. Tau is a key component of neurofbrillary tangles in Alzheimer's disease (AD). Disorders with
Mathuranath, PS, Robert, M
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Pathogenesis of the Tauopathies
Journal of Molecular Neuroscience, 2011Microtubule-associated protein tau is the most commonly misfolded protein in human neurodegenerative diseases, where it becomes hyperphosphorylated and filamentous. Mutations in MAPT, the tau gene, cause approximately 5% of cases of frontotemporal dementia. They are frequently accompanied by parkinsonism. The existence of MAPT mutations has established
Michel, Goedert +1 more
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