Results 61 to 70 of about 309,620 (264)

A Microgel Platform Enables Site‐Specific Intestinal Delivery of Lactoferrin, Improving its Bioavailability for Targeted Alleviating Liver Injury and Colitis

open access: yesAdvanced Science, EarlyView.
This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan   +10 more
wiley   +1 more source

Discovery and Engineering of a Rat Endogenous Retrovirus Reverse Transcriptase for Efficient Prime Editing

open access: yesAdvanced Science, EarlyView.
We screened 558 reverse transcriptases and engineered an optimized rat endogenous retrovirus‐derived variant, enRERV‐RT, via structure‐guided engineering and deep mutational scanning. This enhanced prime editor, based on the engineered RT, outperforms conventional M‐MLV‐RT systems across plant and animal cells, particularly at hard‐to‐edit loci ...
Linsha Ma   +22 more
wiley   +1 more source

Resistant Peanut Genotype Reprograms Rhizosphere Metabolism to Enhance Bacterial Wilt Suppression

open access: yesAdvanced Science, EarlyView.
The resistant peanut genotype selectively recruits beneficial bacteria, which coincides with the activation of salicylic acid (SA)‐dependent systemic acquired resistance (SAR) against Ralstonia solanacearum. Keystone rhizosphere metabolites are positively correlated with both beneficial microbiome assembly and SAR gene expression.
Rui Ren   +20 more
wiley   +1 more source

FLORISTIC CONTRIBUTIONS [PDF]

open access: yesJournal of Plant Development, 2006
The paper represents a part of the research carried out in a five-year period (within my Ph.D. paper called: “The Flora and the Vegetation of the Lower Hydrographic Basin of the River Motru”, coordinated by Professor V. CIOCÂRLAN, Ph.D.).
COSTACHE I.
doaj  

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

open access: yesAdvanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu   +8 more
wiley   +1 more source

Caracterización fenotípica de accesiones de especies de Rubus L. de los municipios de Pamplona y Chitagá, región Nororiental de Colombia

open access: yesUniversitas Scientiarum, 2011
Phenotypical characterization of Rubus L. species accessions in the provinces of Pamplona and Chitagá, northeastern region ofColombia. Objective. Determine the cultivated and wild species of Rubus in 53 commercial farms of Rubus glaucus Benth, owned ...
Enrique Quevedo-García   +3 more
doaj  

Cactáceas endémicas y raras del estado de Chihuahua, México

open access: yesTecnociencia Chihuahua, 2020
Las cactáceas son plantas importantes por su endemismo y amplia distribución en el continente americano. El presente trabajo es el resultado de un mega proyecto que tuvo como objetivo principal, inventariar y registrar todas las especies de ...
Óscar Alejandro Viramontes-Olivas   +5 more
doaj  

L'élevage du "mouton de case" : aspects techniques, socio-économiques et perspectives d'amélioration au Yatenga [PDF]

open access: yesBiotechnologie, Agronomie, Société et Environnement, 2001
Household sheep farming : technical, socoieconomic aspects and improvement prospects in Yatenga (Burkina Faso). The paper presents a technical and socioeconomic analysis of the domestic sheep production and prospects of improvement in the province of ...
Lebailly P.   +5 more
doaj  

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

open access: yesAdvanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai   +7 more
wiley   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

open access: yesAdvanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang   +19 more
wiley   +1 more source

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