Results 51 to 60 of about 58,325 (234)

Endophytic fungus Pseudodidymocyrtis lobariellae KL27 promotes taxol biosynthesis and accumulation in Taxus chinensis

BMC Plant Biology, 2022
Background Taxol from Taxus species is a precious drug used for the treatment of cancer and can effectively inhibit the proliferation of cancer cells. However, the growth of Taxus plants is very slow and the content of taxol is quite low.
Xiaoying Cao, Lingxia Xu, Jingyi Wang, Mengmeng Dong, Chunyan Xu, Guoyin Kai, Wen Wan, Jihong Jiang   +7 more
doaj   +1 more source

The Conformations of Taxol in Chloroform [PDF]

Journal of the American Chemical Society, 2000
Taxol, isolated from the bark of Taxus breVifolia in the late 1960s, 1 and its semisynthetic Taxotere congener 2 have become the drugs of choice for the treatment of ovarian and breast cancer. 3 The availability of active simplified analogues would facilitate shortened synthetic strategies and potentially bypass neurotoxicity 4 and multidrug resistance.
Snyder, JP, Nevins, N, CICERO, DANIEL OSCAR, Jansen, J.   +3 more
openaire   +3 more sources

Effect of blocking Ras signaling pathway with K-Ras siRNA on apoptosis in esophageal squamous carcinoma cells [PDF]

, 2013
ObjectiveTo study the effect of RNAi silencing of the K-Ras gene on Ras signal pathway activity in EC9706 esophageal cancer cells.MethodsEC9706 cells were treated in the following six groups: blank group (no transfection), negative control group ...
Xinjie Wang, Yuling Zheng, Qingxia Fan, Xudong Zhang, Tanaka, Wang, Yoo, Song, Pijnenborg, Chen, Schimanski, Lo, Zhang, Cong, Pu, Li, Margarit, Bar-Sagi, Lovec   +18 more
core   +1 more source

A Serum‐Stable Antimicrobial Peptide‐Based Delivery Platform for Selective Treatment of Nontargetable and Chemoresistant Tumors

Advanced Science, EarlyView.
A modular antimicrobial‐peptide‐based therapeutic system integrating membrane‐targeted selectivity, a conformation‐driven polyethylene glycolylated blocker, and serum‐stabilizing N‐cap is developed. The optimized conjugate 270 shows potent, rapid killing of the desired tumor cells, high serum stability, low off‐target toxicity, and broad applicability,
Tianxing Liu, Lingyu Ke, Ruize Sun, Xiaoling Chen, Mei Zhou, Olaf R. P. Bininda‐Emond, Chengbang Ma, Yangyang Jiang, Tao Wang, Chris Shaw, Lei Wang, Tianbao Chen, Alideertu Dong   +12 more
wiley   +1 more source

Human β-galactoside α-2,3-sialyltransferase (ST3Gal III) attenuated Taxol-induced apoptosis in ovarian cancer cells by downregulating caspase-8 activity [PDF]

, 2009
Taxol triggers apoptosis in a variety of cancer cells, but it also upregulates cytoprotective proteins and/or pathways that compromise its therapeutic efficacy.
Choi, Mi-Ran, Day, Travis W., Huang, Su, Safa, Ahmad R.   +3 more
core   +2 more sources

Identification of a Pair of Linear or Cyclic Naturally Inspired Bifunctional Lipopeptide Antibiotics That Overcome Antimicrobial Resistance

Advanced Science, EarlyView.
The underexplored bacterial genus Aquimarina harbors a large biosynthetic potential for discovering new antibiotics. Here, the authors identify a pair of linear or cyclic bifunctional cationic lipopeptide antibiotics, aquicidine L and C4, inspired by the aquicidine gene cluster from Aquimarina.
Lei Li, Yiwen Zhou, Yuzhu Wu
wiley   +1 more source

Production and bioprocessing of Taxol from Aspergillus niger, an endophyte of Encephalartos whitelockii, with a plausible biosynthetic stability: antiproliferative activity and cell cycle analysis

Microbial Cell Factories
The biosynthetic potency of Taxol by fungi raises their prospective to be a platform for commercial production of Taxol, nevertheless, the attenuation of its productivity with the fungal storage, is the challenge.
Asmaa Gamal, Eman Fikry, Nora Tawfeek, Azza M. El-Shafae, Ashraf S. A. El-Sayed, Maher M. El-Domiaty   +5 more
doaj   +1 more source

Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation

Scientific Reports, 2017
Taxol, a first-line anti-tumour drug, has low effectiveness against colorectal cancer. Combination with other agents is an effective strategy to enhance Taxol cytotoxicity.
Yijia Wang, Chunze Zhang, Shiwu Zhang, Zhenying Zhao, Jiawen Wang, Jiali Song, Yue Wang, Jun Liu, Shaobin Hou   +8 more
doaj   +1 more source

The mechanism of anaphase spindle elongation: uncoupling of tubulin incorporation and microtubule sliding during in vitro spindle reactivation. [PDF]

, 1988
To study tubulin polymerization and microtubule sliding during spindle elongation in vitro, we developed a method of uncoupling the two processes. When isolated diatom spindles were incubated with biotinylated tubulin (biot-tb) without ATP, biot-tb was ...
CANDE, W. Zacheus, Masuda, H, McDonald, K   +2 more
core  

The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells

Advanced Science, EarlyView.
This study uncovers a previously unknown crosstalk between two major ubiquitin ligases, CRL5 and APC/C. The authors identify APC11 as a binding partner of CUL5, showing that their interaction regulates neddylation, substrate stability, and mitotic progression.
Danrui Cui, Ruirui Qu, Tianqi Li, Linchen Wang, Xiaoyu Chen, Shengpeng Shao, Xue Liang, Jun Xu, Yi Sun, Xiufang Xiong, Yongchao Zhao   +10 more
wiley   +1 more source