Results 81 to 90 of about 58,325 (234)

Exploiting the Biosynthetic Potency of Taxol from Fungal Endophytes of Conifers Plants; Genome Mining and Metabolic Manipulation

open access: yesMolecules, 2020
Endophytic fungi have been considered as a repertoire for bioactive secondary metabolites with potential application in medicine, agriculture and food industry.
Ashraf S.A. El-Sayed   +8 more
doaj   +1 more source

Screening and characterization of fungal taxol-producing endophytic fungi for evaluation of antimicrobial and anticancer activities

open access: yesOpen Chemistry, 2023
Bioactive compounds produced by fungal endophytes have potential benefits, such as low cost, rapid growth, facile genetic manipulation, and industrial scale-up with fewer negative effects.
Pandy Rajapriya   +6 more
doaj   +1 more source

Polyethylene Glycol‐Functionalized Graphene Oxide Nanocomposites: Advances in Biomedical Applications

open access: yesNano Select, EarlyView.
Polyethylene glycol‐functionalized graphene oxide (PEG‐GO) nanocomposites revolutionize nanomedicine with their high surface area and tunable properties. This review explores their synthesis, characterization, and applications in drug delivery, gene therapy, biosensing, and photothermal therapy.
Oluwasegun Chijioke Adekoya   +4 more
wiley   +1 more source

Nanomedicine for Oral Delivery: Strategies to Overcome the Biological Barriers

open access: yesSmall Methods, EarlyView.
Oral delivery is a preferred administration route for many clinical applications, valued for its strong patient compliance. In this review, how nanoparticles are engineered and deployed to overcome the gastrointestinal barriers that impede clinical translation of oral delivery formulations is examined.
Luke J. Kubiatowicz   +5 more
wiley   +1 more source

In vitro reactivation of spindle elongation in fission yeast nuc2 mutant cells. [PDF]

open access: yes, 1990
To investigate the mechanisms of spindle elongation and chromosome separation in the fission yeast Schizosaccharomyces pombe, we have developed an in vitro assay using a temperature-sensitive mutant strain, nuc2.
Cande, WZ   +3 more
core  

Linear scaling computation of the Fock matrix. IX. Parallel computation of the Coulomb matrix

open access: yes, 2004
We present parallelization of a quantum-chemical tree-code [J. Chem. Phys. {\bf 106}, 5526 (1997)] for linear scaling computation of the Coulomb matrix. Equal time partition [J. Chem. Phys.
C. J. Tymczak   +3 more
core   +1 more source

Imaging malaria parasites across scales and time

open access: yesJournal of Microscopy, EarlyView.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source

A Review on Taxol Production through Biotechnological Approaches

open access: yesJournal of Medicinal Plants, 2018
Taxol is a very important anticancer drug which was first isolated from Yew plant (Taxus spp.). However, Taxol supply by extraction from natural sources, has several limitations, and cannot meet current marketchr('39')s demands.
M Majidi, AR tarinejad
doaj  

Down-regulated βIII-tubulin Expression Can Reverse Paclitaxel Resistance in A549/Taxol Cells Lines

open access: yesChinese Journal of Lung Cancer, 2014
Background and objective Chemotherapy drug resistance is the primary causes of death in patients with pulmonary carcinoma which make tumor recurrence or metastasis. β-tubulin is the main cell targets of anti-microtubule drug. Increased expression of βIII-
Yinling ZHUO, Qisen GUO
doaj   +1 more source

Protein engineering strategies to optimise recombinant product synthesis and accumulation in Nicotiana benthamiana

open access: yesPlant Biotechnology Journal, EarlyView.
Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
wiley   +1 more source

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