Results 131 to 140 of about 22,844 (235)

Abdominal Wall Abscess after Prophylactic Percutaneous Endoscopic Gastrostomy Placement in a Patient Undergoing Chemoradiotherapy for Laryngeal Cancer

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Prophylactic percutaneous endoscopic gastrostomy (PEG) placement for nutritional management prior to chemoradiotherapy is a common procedure in patients with head and neck cancer, for which serious complications are rare. Herein, we present a case of abdominal wall abscess that developed 12 days following prophylactic PEG placement in a ...
Ryuji Okamoto, Hironori Sunakawa, Yuji Owaki, Hiroaki Oka, Yuta Hoshi, Susumu Okano, Tomonori Yano   +6 more
wiley   +1 more source

Artificial intelligence and multi-omics nominate TAZ as an insomnia-related diagnostic and druggable target for Parkinson's disease patients. [PDF]

Front Aging Neurosci
Ma W.
europepmc   +1 more source

A GIS‐Integrated Active Learning Framework for Crash Severity Classification in Imbalanced Traffic Data

Transactions in GIS, Volume 30, Issue 2, April 2026.
ABSTRACT Classifying urban traffic crash severity remains challenging because severe incidents are underrepresented in highly imbalanced datasets. This challenge is further intensified by spatiotemporal shifts in data distributions, which can degrade model performance over time.
Reza Mohammadi, Mohammad Taleai
wiley   +1 more source

Calcium Hydroxylapatite Injection Improves Senile Purpura via YAP‐Mediated Mechanotransduction

International Journal of Dermatology, EarlyView.
Jimyung Seo, HyunSeok Kim, Boncheol Leo Goo, Je‐Young Park, Nark‐Kyoung Rho, Solam Lee   +5 more
wiley   +1 more source

From Single‐Cell Clusters to Causality: ITCH Engagement for CKD Uncovered by Integrative Analysis of MR and MAGMA

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
This graphical abstract illustrates an integrative analysis of single‐cell RNA‐seq data in CKD. DEGs were subsequently identified as candidate genes via Mendelian randomization analysis and combined with MAGMA analysis, ITCH was identified as a key gene.
Xia Zhang, Dongdong Zhang, Jiazhen Shang, Zhitao Zeng, Shouyu Chai, Xincong Lv, Zhimei Lv, Rong Wang   +7 more
wiley   +1 more source

Targeting Hippo-YAP/TAZ signaling pathway: an updated review demonstrating the therapeutic potential of key plant derived anticancer compounds. [PDF]

Front Pharmacol
Elsori D, Pandey P, Alshaikh K, Alkhathami AG, Saeed M, Singh A, Khan F.   +6 more
europepmc   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

YAP/TAZ-VGLL3 governs adipocyte fate via epigenetic reprogramming of PPARγ and its target enhancers. [PDF]

Sci Adv
Seol T, Kang JG, Ryu K, Kim W, Hwang D, Cho S, Song D, Ku B, Tran YTH, Jeong SH, Cho WK, Lim DS.   +11 more
europepmc   +1 more source

Disrupting the Formation of YAP Condensates Promotes the Activation of AMPKα to Inhibit the Progression of Primary Liver Cancer

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This study systematically investigates the function and molecular mechanisms of YAP phase separation in multiple primary liver cancers. These findings provide novel insights into phase separation‐mediated primary liver cancer development and validate targeted disruption of this process as an effective therapeutic strategy for primary liver cancer ...
Shuang‐Zhou Peng, Jia‐Jia Liang, Yun‐Feng Zhan, Wei‐Xun Wu, Wan‐Li Xu, Xiao‐Kun Zhang, Li‐Jun Cai, Fu‐Quan Jiang   +7 more
wiley   +1 more source

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

Advanced Science, Volume 13, Issue 16, 18 March 2026.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao, Ruohui Han, Hui Xiong, Qian Li, Shaofei Tao, Xudong Wu, Dayong Liu   +6 more
wiley   +1 more source