Results 11 to 20 of about 76,145 (237)
mBio, 2022 β-Lactamases hydrolyze β-lactam antibiotics and are major determinants of antibiotic resistance in Gram-negative pathogens. Enmetazobactam (formerly AAI101) and tazobactam are penicillanic acid sulfone (PAS) β-lactamase inhibitors that differ by an ...
Philip Hinchliffe +10 more
doaj +1 more source
Antibiotics, 2021 Environmental monitoring, particularly of water, is crucial to screen and preselect potential hazardous substances for policy guidance and risk minimisation strategies. In Portugal, extensive data are missing.
Paula Viana +10 more
doaj +1 more source
Antibiotics, 2020 The aim of this study was to develop a population pharmacokinetic model for piperacillin (PIPC)/tazobactam (TAZ) in late elderly patients with pneumonia and to optimize the administration planning by applying pharmacokinetic/pharmacodynamic (PK/PD ...
Noriyuki Ishihara +9 more
doaj +1 more source
Silver(I)-Tazobactam Frameworks with Improved Antimicrobial Activity
Frontiers in Chemistry, 2022 Tazobactam (TazoH) is a penicillinate sulfone β-lactamase inhibitor with negligible antimicrobial activity, commonly used with other antibiotics to provide an effective combination against many susceptible organisms expressing β-lactamases.
Daniela R. Ferreira +8 more
doaj +1 more source
Antibiotics, 2023 Implant-associated osteomyelitis is one of the most feared complications following orthopedic surgery. Although the risk is low, sufficient antibiotic protection of the implant surface is important.
Johanne Gade Lilleøre +8 more
doaj +1 more source
Incidence of acute kidney injury in critically ill patients receiving vancomycin with concomitant piperacillin-tazobactam, cefepime, or meropenem [PDF]
, 2019 Critically ill patients are frequently treated with empirical antibiotic therapy, including vancomycin and -lactams. Recent evidence suggests an increased risk of acute kidney injury (AKI) in patients who received a combination of vancomycin and ...
Blevins, Adam M +5 more
core +2 more sources
Population Pharmacokinetics and Pharmacodynamics of Extended-Infusion Piperacillin and Tazobactam in Critically Ill Children [PDF]
, 2015 The study objective was to evaluate the population pharmacokinetics and pharmacodynamics of extended-infusion piperacillintazobactam in children hospitalized in an intensive care unit.
Buenger, Lauren E. +7 more
core +2 more sources
Successful ceftolozane/tazobactam treatment of chronic pulmonary infection with pan‐resistant Pseudomonas aeruginosa [PDF]
, 2015 The treatment of chronic Pseudomonas aeruginosa infections is challenging, with resistance and antibiogram diversity accumulating during successive therapies.
Andrews +9 more
core +1 more source
Molecules, 2020 FT-IR/ATR analytical technique is one of the most applicable techniques worldwide. It is closely associated with easy-to-use equipment, rapid analysis, and reliable results. This study reports the simultaneous qualitative and quantitative analysis of two
Ioanna Chrisikou +2 more
doaj +1 more source
Lung penetration, bronchopulmonary pharmacokinetic/pharmacodynamic profile and safety of 3 g of ceftolozane/tazobactam administered to ventilated, critically ill patients with pneumonia [PDF]
, 2020 Objectives: Ceftolozane/tazobactam is approved for hospital-acquired/ventilator-associated bacterial pneumonia at double the dose (i.e. 2 g/1 g) recommended for other indications.
Adedoyin, Adedayo +9 more
core +1 more source