Results 31 to 40 of about 37,775 (207)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Solidification and Stabilization of Spent TBP/OK Organic Liquids in a Phosphate Acid-Based Geopolymer

Science and Technology of Nuclear Installations, 2020
A method for solidifying spent tributyl phosphate and kerosene (TBP/OK) organic liquids in a phosphate acid-based geopolymer (PAG) was investigated. The TBP/OK emulsion containing tween 80 (T80), TBP/OK organic liquids, and H3PO4 was prepared. The TBP/OK
Teng Dong, Shuibo Xie, Jingsong Wang, Guodong Zhao, Qingchun Song   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

TFIIA Regulates TBP and TFIID Dimers [PDF]

Molecular Cell, 1999
Dimerization of the TATA-binding protein (TBP) through its DNA-binding domain blocks TBP from accessing DNA and prevents unregulated gene expression. TFIIA plays a central role in loading TBP and its multisubunit counterpart TFIID onto promoter DNA, and it is therefore a candidate for regulating TBP/TFIID dimerization. Here, we show that TFIIA promotes
Coleman, Robert A, Taggart, Andrew K.P, Burma, Sandeep, Chicca II, John J, Pugh, B.Franklin   +4 more
openaire   +2 more sources

Research on Primary Radiolysis Products of TBP Using Exogenous Alpha Particles

Yuanzineng kexue jishu
In the spent fuel reprocessing process, extractants and extraction systems are subjected to intense radiation from various types of rays. Under such strong radiation fields, these extractants inevitably undergo physicochemical changes, such as chemical ...
ZHANG Runyu, SHI Shilong, WAN Yaoshuang, SONG Jiajian, QU Guofeng, LI Feize, YANG Yuanyou, LIAO Jiali, LIU Ning
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Evolutionary history of the TBP-domain superfamily [PDF]

Nucleic Acids Research, 2013
The TATA binding protein (TBP) is an essential transcription initiation factor in Archaea and Eucarya. Bacteria lack TBP, and instead use sigma factors for transcription initiation. TBP has a symmetric structure comprising two repeated TBP domains.
Brindefalk, Björn, Dessailly, Benoit H., Yeats, Corin, Orengo, Christine, Werner, Finn, Poole, Anthony M.   +5 more
openaire   +2 more sources

Characteristics and Performance of Cerium Extraction from Cerium Hydroxide Concentrate using Tri Butyl Phosphate

International Journal of Technology
This study aims to develop a liquid-liquid equilibrium model to predict the Ce distribution in the extraction system based on experimental laboratory data.
Suyanti, Nur Dewi Pusporini, Wisnu Ari Adi, Himawan Tri Bayu Murti Petrus   +3 more
doaj   +1 more source

Architecture of TAF11/TAF13/TBP complex suggests novel regulation properties of general transcription factor TFIID

eLife, 2017
General transcription factor TFIID is a key component of RNA polymerase II transcription initiation. Human TFIID is a megadalton-sized complex comprising TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs).
Kapil Gupta, Aleksandra A Watson, Tiago Baptista, Elisabeth Scheer, Anna L Chambers, Christine Koehler, Juan Zou, Ima Obong-Ebong, Eaazhisai Kandiah, Arturo Temblador, Adam Round, Eric Forest, Petr Man, Christoph Bieniossek, Ernest D Laue, Edward A Lemke, Juri Rappsilber, Carol V Robinson, Didier Devys, Làszlò Tora, Imre Berger   +20 more
doaj   +1 more source