Results 91 to 100 of about 2,037,833 (287)

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

Alternative scenarios of flux through the TCA cycle.

, 2013
(A) The conventional closed bacterial TCA cycle via the OGDH complex. (B) A bypass recently identified by Zhang and Bryant [49]. (C ) The glyoxylate shunt as a bypass of the TCA cycle, as utilized in the reconstruction of Shastri and Morgan [10]. (D) The
Wolfgang Lockau (427971), Robert Lehmann (427970), Sabrina Hoffmann (25174), Marianne Gründel (427969), Ralf Steuer (56833), Yvonne Zilliges (227065), Henning Knoop (427968)   +6 more
core   +1 more source

A thermodynamic bottleneck in the TCA cycle contributes to acetate overflow in Staphylococcus aureus

mSphere
During aerobic growth, S. aureus relies on acetate overflow metabolism, a process where glucose is incompletely oxidized to acetate, for its bioenergetic needs. Acetate is not immediately captured as a carbon source and is excreted as waste by cells. The
Nabia Shahreen, Jongsam Ahn, Adil Alsiyabi, Niaz Bahar Chowdhury, Dhananjay Shinde, Sujata S. Chaudhari, Kenneth W. Bayles, Vinai C. Thomas, Rajib Saha   +8 more
doaj   +1 more source

Coordination‐Tuned Iridium Single‐Atom Nanozymes Boost Multienzyme Activity for Colorimetric Sensing

Advanced Science, EarlyView.
Breaking the coordination symmetry of Ir single‐atom sites through asymmetric Ir–N3S1 engineering tailors interfacial electron transfer, oxygen activation, and multienzyme‐like catalytic pathways. Operando spectroscopy and theoretical modeling uncover the atomic‐level origin of activity enhancement, providing a strategy for designing multifunctional ...
Tao Li, Xinyu Zhang, Jiashan Xia, Mengyu Wu, Cong Liu, Yapei Sun, Wanjiang Zhao, Min Qian, Wei Wang, Weixia Duan, Shangcheng Xu   +10 more
wiley   +1 more source

TCA cycle metabolism genes.

, 2012
Genes associated with TCA cycle metabolism were identified from among the significantly differentially expressed probe sets between HFD-fed WT and Ogg1−/− mice, using gene ontology terms in Gene Sifter.
Vladimir Vartanian (110280), Yusaku Nakabeppu (57909), M. Rick Rollins (110282), Kunihiko Sakumi (57908), Harini Sampath (110278), R. Stephen Lloyd (110287)   +5 more
core   +1 more source

Chemoselective Metabolomics via a Modular Reactivity‐Encoding Platform

Advanced Science, EarlyView.
Conventional LC–MS underrepresents numerous metabolites due to heterogeneous ionization efficiencies and matrix interference. Here, we introduce a modular reactivity‐encoding platform (MREP) comprising four alkyne‐tagged probes that selectively derivatize key functional groups, followed by unified click‐chemistry capture to eliminate matrix components ...
Xin Tao, Cang‐Man Zhang, Ru‐Jie Yang, Min Ren, Zhuo‐Ling Zhong, Kang‐Hui Wang, Rui‐Xue Hu, Jia‐Yue Liu, Jun‐Yi Zhou, Hou‐Kai Li, Jian‐Bo Wan   +10 more
wiley   +1 more source

Correlation of plasma itaconate concentrations with TCA cycle intermediates.

, 2021
Plasma concentrations of itaconate were significantly and negatively correlated with TCA cycle intermediates (A) succinate, (B) fumarate and (C) malate. (TIF)
Dean P. Jones (180039), Ken H. Liu (5848607), Manoj Khadka (5848610), Thomas R. Ziegler (9155143), James C. M. Brust (11478771), Rafick-Pierre Sékaly (118474), Eric A. Ortlund (7352939), Henry M. Blumberg (7348961), Kristal Maner-Smith (11478765), Neel R. Gandhi (7292717), Russell R. Kempker (7348955), Ashish Sharma (319838), N. Sarita Shah (11478768), Jeffrey M. Collins (5753942), Brendan Prideaux (1604743), Nestani Tukvadze (333421)   +15 more
core   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Elementary flux modes of TCA cycle and their overall reactions.

, 2013
Elementary flux modes of TCA cycle and their overall reactions.
Liza Felicori (477651), Sabine Pérès (477650), Franck Molina (86932)   +2 more
core   +1 more source

Dysregulated Tricarboxylic Acid Cycle Metabolism Is Associated With Right Ventricular Maladaptation in Pulmonary Vascular Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Right ventricular (RV) maladaptation to elevated pulmonary afterload is the primary determinant of outcomes in pulmonary artery (PA) hypertension; however, the pathobiological mechanisms underlying RV decompensation remain poorly understood ...
Darin T. Rosen, Todd M. Kolb, Stephen C. Mathai, Karthik Suresh, Rachel Damico, Steven Hsu, Ryan J. Tedford, Anna R. Hemnes, Jane A. Leopold, Evelyn M. Horn, Erika S. Berman‐Rosenzweig, Franz Rischard, Robert P. Frantz, Serpil C. Erzurum, Gerald J. Beck, Nicholas S. Hill, John Barnard, Samar Farha, Gabriele Grunig, Christine Jellis, Deborah H. Kwon, Reena Mehra, Margaret M. Park, W. H. Wilson Tang, Paul M. Hassoun, Catherine E. Simpson   +25 more
doaj   +1 more source