Results 81 to 90 of about 2,037,833 (287)

The Tca Cycle As A Nexus of Metabolic Vulnerabilities In Cancer [PDF]

, 2022
Uncontrolled proliferation of cancer cells necessitates rewiring of metabolic pathways to meet biosynthetic and bioenergetic demands of proliferation and fortify redox homeostasis.
Khadka, Sunada
core   +1 more source

Dysfunctional TCA-Cycle Metabolism in Glutamate Dehydrogenase Deficient Astrocytes

, 2015
Astrocytes take up glutamate in the synaptic area subsequent to glutamatergic transmission by the aid of high affinity glutamate transporters. Glutamate is converted to glutamine or metabolized to support intermediary metabolism and energy production ...
Skytt, Dorte M, Pajęcka, Kamilla, Stridh, Malin H, Waagepetersen, Helle S, Nissen, Jakob D   +4 more
core   +1 more source

An Efficient Detection Platform Based on Mesoporous Au@Cr2O3 Particles with Schwarz P Surface for Precise Periodontitis Metabolite Profiling

Advanced Science, EarlyView.
A non‐invasive periodontitis diagnosis platform was developed using Au nanoparticles‐decorated mesoporous Cr2O3 (Au@mCr2O3) particles with Schwarz P surface as matrix for saliva metabolic fingerprinting (SMFs) analysis via MALDI‐MS. With the assistance of machine learning of SMFs, this platform enables efficient diagnosis and the screening of potential
Yue Sun, Yan Wang, Fangying Shi, Wenhe Xie, Yiding Zhang, Heyuhan Zhang, Chunhui Deng, Limin Wu, Meihua Chen, Yonghui Deng   +9 more
wiley   +1 more source

Protocole de prélèvement des TCA

, 2015
L'intérêt d'étudier les terres cuites architecturales est devenu indéniable, pour des questions de chronologie, d'architecture, d'histoire des techniques et d'histoire économique et sociale.
Étienne Jaffrot
core  

Metabolites of Fatty Acid Synthesis and TCA Cycle.

, 2013
Metabolites of Fatty Acid Synthesis and TCA Cycle.
Kathleen M. Gura (397597), Brian T. Kalish (397596), Hau D. Le (343378), Mark Puder (343382), Bruce R. Bistrian (397598)   +4 more
core   +1 more source

Metabolic coupling of ROS generation and antioxidant synthesis by the GABA shunt pathway in myeloid-like blood progenitor cells of Drosophila.

PLoS Genetics
Redox balance is crucial for normal development of stem and progenitor cells that reside in oxidative environments. In this study, we explore the mechanisms of redox homeostasis in such niches and show that myeloid-like blood progenitor cells of the ...
Manisha Goyal, Sakshi Tiwari, Jagriti Arora, Bruce Cooper, Ramaswamy Subramanian, Tina Mukherjee   +5 more
doaj   +1 more source

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

Parameters of TCA cycle reactions and substrate transport.

, 2012
Parameters of TCA cycle reactions and substrate transport.
Mark Friedman (133553), Mark F. Schumaker (133556), Massimo Trucco (10178), Tatyana V. Votyakova (133559), Vitaly A. Selivanov (133548), Marta Cascante (67954)   +5 more
core   +1 more source

Cobalt Single‐Atom Nanozyme for Enhanced Intestinal Radioprotection and Tumor Radiosensitization via Bidirectional ROS Modulation

Advanced Science, EarlyView.
Orally administered, pH‐responsive Co‐SAN exerts dual functions: in the alkaline intestinal milieu, it scavenges reactive oxygen species (ROS) and suppresses the PI3K/AKT pathway and NETs formation, thus providing radioprotection; whereas in the acidic tumor microenvironment, it generates ROS and alleviates hypoxia, thereby enhancing radiosensitization.
Shengqi Yin, Junjie Li, Yishu Zou, Yang Liu, Yilin Zheng, Lu Yu, Wanying Zheng, Yajun Zou, Zehui Zhang, Tao Li, Peiqun Yin, Jianlin Zhang, Yuen Wu, Yi Ding   +13 more
wiley   +1 more source

TCA cycle (black arrows) and glyoxylate cycle (dashed arrows).

, 2014
In both cycles, oxaloacetate serves as the precursor for gluconeogenesis, but the glyoxylate cycle bypasses the carbon dioxide generating steps of the TCA cycle via isocitrate lyase and malate synthase, thus conserving the carbons for gluconeogenesis ...
Hong-Leong Cheah (556534), Doblin Sandai (556536), Vuanghao Lim (556535)   +2 more
core   +1 more source