Results 151 to 160 of about 249,034 (202)
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Pathway classification of TCA cycle
IEE Proceedings - Systems Biology, 2006The structural analysis of large metabolic networks exhibits a combinatorial explosion of elementary modes. A new method of classification has been developed [called aggregation around common motif (ACoM)], which groups elementary modes into classes with similar substructures.
Pérès, S. +2 more
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Upcycling the TCA cycle—rewiring tumour-associated fibroblasts
Nature Metabolism, 2021Alterations to the extracellular matrix have long been associated with cancer progression and therapeutic resistance. Schworer et al. describe a mechanism whereby fibroblasts reroute metabolites to fuel the demands of collagen synthesis, leading to cancer progression.
Zachary A. Bacigalupa +1 more
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Regulation of the urea cycle and TCA cycle by ammonia
Advances in Enzyme Regulation, 1966Abstract This paper presents the biochemical and enzymatic fundamentals of ammonia toxicity and automatic regulation of urea formation from ammonia. 1. 1.It is considered that the oxidation of isocitrate to 2-oxoglutarate is more sensitive to ammonia than the other dehydrogenases in the TCA cycle. 2.
N, Katunuma, M, Okada, Y, Nishii
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TCA cycle off, ATF4 on for metabolic homeostasis
Trends in Biochemical Sciences, 2022Tricarboxylic acid (TCA) cycle is a major hub for catabolic and anabolic reactions, yet cellular metabolic adaptations following its inhibition are largely unknown. Using multi-tiered omics approaches, Ryan et al. have shown convergent activation of the integrated stress response (ISR) through ATF4-mediated rewiring of cellular amino acid and redox ...
Durga Mahor +2 more
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TCA Cycle Defects in Barth Syndrome
The FASEB Journal, 2016Barth syndrome (BTHS) is a genetic disorder caused by defective remodeling of the phospholipid cardiolipin (CL) due to mutations in the gene coding for tafazzin. The disorder is characterized by dilated cardiomyopathy and mitochondrial dysfunction. CL is a unique membrane lipid that has multiple cellular functions.
Wenjia Lou +8 more
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Glutamine drives glucose-independent TCA cycle
Journal of Cancer Science & Therapy, 2012Methods: We used high-field NMR, in parallel with GC-MS, and direct infusion nanospray FT-ICR-MS as well as stable isotoperesolved metabolomics to trace the fate of 13C and 15N from labeled glucose or glutamine in the P493 human B lymphoma under aerobic, hypoxic glucose-deprived conditions.
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Synthetic metabolism without the TCA cycle
Nature Metabolism, 2022Steffen N. Lindner, Markus Ralser
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The Truncated TCA Cycle in HeLa Cell Mitochondria
1992A series of studies were carried out on HeLa cell mitochondria to determine (1) the likely pathways for carbon flux from glutamate, (2) the significance of malic enzyme activity, (3) the significance of pyruvate dehydrogenase activity, and finally (4) the significance of the truncated TCA cycle in HeLa cells (Coleman and Lavietes, 1981).
T J, Piva, E, McEvoy-Bowe
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Metabolic engineering: Kick-starting TCA cycling
Nature Plants, 2015The tricarboxcylic acid cycle has been exhaustively studied for decades so it is not unreasonable to expect that it would retain few undiscovered surprises. However, experimental analyses in cyanobacteria show it to be remarkably plastic, dependent on what it is producing and how much.
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