Results 201 to 210 of about 2,037,833 (287)

Differential activation of TCA cycle activity and PDH flux by dichloroacetate in skeletal muscle measured by hyperpolarized [2-¹³C,3-²H₃]pyruvate. [PDF]

iScience
Lin SH, Cho A, Huynh MT, Erfani Z, Kucejova B, Dewage SW, Jue T, Fu X, Kovács Z, Burgess SC, Park JM.   +10 more
europepmc   +1 more source

Designing Governance for ESG: Incentive and Oversight Complementarities in Corporate Sustainability Performance

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study investigates how internal governance design supports credible ESG performance by distinguishing between Incentive and Oversight Architectures. Using 13,993 firm‐year observations of US nonfinancial firms from 2018 to 2024, we estimate fixed effects and two‐step system GMM models.
Beyza Gürel, Nehir Balci, Mustafa Reha Okur   +2 more
wiley   +1 more source

Antidepressant Misuse in Esports: A Review of Pharmacology, Adverse Effects, Pharmacokinetics and Biomatrix‐Based Detection for Anti‐Doping Applications

Drug Testing and Analysis, EarlyView.
This review highlights the misuse of antidepressants as potential cognitive‐enhancing agents in Esports. Despite pharmacological effects that overlap with those of psychostimulants, antidepressants remain an under‐recognised source of doping in Esports.
Kassim Ali Salum, Shao‐Hsin Hung, Meng‐Tsang Hsieh, Mei‐Chich Hsu, William Chih‐Wei Chang   +4 more
wiley   +1 more source

A Citrate Synthase Splice Variant Rewires the TCA Cycle to Promote Colorectal Cancer Progression. [PDF]

Cancer Res
Cheung JCT, Ng LW, Zhu Z, Chen B, Li S, Xu M, Ding X, Pu D, Hu Y, Ren Y, Kang W, Li M, Wong JWH, Wang X, Cheng YK, Aik WS, Wong KL, Ng SSM, Wong N, Dong Y.   +19 more
europepmc   +1 more source

Mechanism and disaster control new technology of strong ground pressure manifestation in ultra‐large mining face

Deep Underground Science and Engineering, EarlyView.
In response to the problem of strong mining pressure manifestation along the goaf roadway in a thick coal seam mining area, this study uses a new type of combined blasting roof cutting technology to effectively control the manifestation and deformation of mining pressure along the goaf roadway.
Xiaoding Xu, Manchao He, Jun Yang, Yubing Gao, Qiang Fu, Qing Ma, Yajun Wang   +6 more
wiley   +1 more source

Fungal infection drives metabolic reprogramming in epithelial cells via aerobic glycolysis and an alternative TCA cycle shunt. [PDF]

Sci Adv
Pellon A, Sadeghi Nasab SD, Bidkhori G, Griffiths JS, Vaga S, Begum N, Blagojevic M, Sigh NK, Kotowicz NK, Uzochukwu I, Le Guennec A, Henley-Smith R, Gregson-Williams H, Clasen F, Pryce M, Karimpour N, Cook R, Anguita J, Richardson JP, Thavaraj S, Naglik JR, Shoaie S, Moyes DL.   +22 more
europepmc   +1 more source

An accessible microfluidic perfusion platform for time‐restricted control of zebrafish embryonic patterning

Developmental Dynamics, EarlyView.
Abstract Understanding the dynamic nature of developmental networks requires live imaging techniques capable of capturing real‐time developmental processes in wild‐type and mutant embryos as they are exposed to pharmacological perturbations. A peculiar developmental patterning process in early vertebrate embryos is the sequential segmentation of ...
Mohammed Nakhuda, M. Fethullah Simsek
wiley   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

Upregulation of the TCA Cycle and Oxidative Phosphorylation Enhances the Fitness of CD99 CAR-T Cells Under Dynamic Cultivation. [PDF]

Int J Mol Sci
Zhao J, Wang Y, Wang Y, Dong G, Wu H, Cui Y, Gu L, Zhao F, Zhao G, Kang J, Zhang Q, Liu N, Wang N, Sun X, Xu Y, Zhang T, Shi J.   +16 more
europepmc   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source