Results 91 to 100 of about 26,882 (189)

MYC in Oncogenesis and Therapeutic Implications

MedComm, Volume 7, Issue 8, August 2026.
The MYC oncogene family (c‐MYC, N‐MYC, L‐MYC) functions as a central transcriptional hub orchestrating cancer progression through multiple interconnected pathways. This graphical abstract illustrates MYC's role as a multidimensional regulator positioned at the nexus of tumor microenvironment remodeling, metabolic reprogramming, and therapeutic ...
Na Zhang, Li Wei, Cuiping Tang, Peilong Lai, Wenbin Zhong, Hua You   +5 more
wiley   +1 more source

KLF4 and SOX9 transcription factors antagonize β-catenin and inhibit TCF-activity in cancer cells

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012
The transcriptional activator β-catenin is a key mediator of the canonical Wnt signaling pathway. β-catenin itself does not bind DNA but functions via interaction with T-cell factor (TCF)/lymphoid-enhancing factor (LEF) transcription factors. Thus, in the case of active Wnt signaling, β-catenin, in cooperation with TCF/LEF proteins family, activates ...
Sellak, Hassan, Wu, Songwei, Lincoln, Thomas M.   +2 more
openaire   +2 more sources

Single‐Cell Virtual Perturbation Screening Identifies STAT3 as a Key Regulator of Dentinogenesis

Cell Proliferation, Volume 59, Issue 8, August 2026.
STAT3 promotes odontoblast differentiation in dental mesenchymal cells by transcriptionally regulating WNT2B via the canonical Wnt/β‐catenin signalling pathway. These findings elucidate a mechanism underlying dentine development. ABSTRACT Dentine formation constitutes a physiological process precisely regulated by signal transduction modules governing ...
Yanfei Zhu, Hongyuan Xu, Zijian Zhang, Siyuan Sun, Zihan Huang, Xin Gao, Houwen Pan, Xiangru Huang, Yuanqi Liu, Xinyu Wang, Hanbin Jia, Qinggang Dai, Lingyong Jiang   +12 more
wiley   +1 more source

Unexpected Promotion of Bone Regeneration by Inhibition of BMPR1A‐Mediated BMP Signalling

Cell Proliferation, Volume 59, Issue 8, August 2026.
BMPR1A downregulation reduces ID1, releases TCF3 to activate GNG4‐PI3K‐AKT signalling, thereby promoting OPC proliferation and bone regeneration. ABSTRACT Bone morphogenetic protein (BMP) signalling plays a pivotal role in bone regeneration by regulating osteoprogenitor cell (OPC) function, and BMPs have been widely used in clinical treatment. However,
Zihao Zhou, Yun Zhai, Xiaochen Liu, Jiaojiao Shao, Jiani Zhou, Zhaoyang Li, Jiale He, Shuxian Lin, Qi Zhang   +8 more
wiley   +1 more source

Mechanotransduction of Collagen Biostimulators: Comparative Signaling and Implications for GLP‐1 RA–Associated Facial Aging

Journal of Cosmetic Dermatology, Volume 25, Issue 8, August 2026.
ABSTRACT Background GLP‐1 receptor agonists (GLP‐1 RAs) can induce rapid weight reduction, often associated with facial volume loss. However, optimal regenerative strategies remain unclear. Aims To compare the mechanotransduction profiles of the major injectable collagen biostimulator classes in GLP‐1 RA–induced facial aging.
Chang‐Hwan Cho, Atsuko Yanagawa, Beomjoon Kim   +2 more
wiley   +1 more source

Transcriptional and epigenetic regulation of follicular T-helper cells and their role in autoimmunity

Autoimmunity, 2017
T-follicular helper (Tfh) cells are a specialized subset of T cells that provide help to B cells and promote the formation of germinal centers (GCs). Tfh cells transmit important signals to B cells that drive class switch recombination, somatic hyper ...
Hong Qiu, Haijing Wu, Vera Chan, Chak-Sing Lau, Qianjin Lu   +4 more
doaj   +1 more source

TCF Transcription Factors, Mediators of Wnt-Signaling in Development and Cancer

Developmental Biology, 2002
van Noort, Mascha, Clevers, Hans
openaire   +4 more sources

Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells

Mediators of Inflammation, 2015
Recent studies on innate lymphoid cells (ILCs) have expanded our knowledge about the innate arm of the immune system. Helper-like ILCs share both the “innate” feature of conventional natural killer (cNK) cells and the “helper” feature of CD4+ T helper ...
Chao Zhong, Jinfang Zhu
doaj   +1 more source

β-Catenin: A Key Molecule in Osteoblast Differentiation

Biomolecules
β-catenin is a key regulator of osteoblast differentiation, proliferation, and bone homeostasis. Through its interaction with transcription factors such as TCF/LEF, Runx2, and Osx, it coordinates gene expression essential for osteogenesis.
Edyta Wróbel, Piotr Wojdasiewicz, Agnieszka Mikulska, Dariusz Szukiewicz   +3 more
doaj   +1 more source

Molecular Crosstalk Between SIRT1, Wnt/β-Catenin Signaling, and Inflammatory Pathways in Renal Transplant Rejection: Role of miRNAs, lncRNAs, IL-1, IL-6, and Tubulointerstitial Inflammation

Medicina
Background/Objectives: This study aimed to evaluate the relationship between sirtuin family members (SIRT1, SIRT3, and SIRT6) and Wnt/β-catenin pathways with inflammation during the rejection process following kidney transplantation, as well as to ...
Nurhak Aksungur, Murat Kizilkaya, Necip Altundaş, Eda Balkan, Salih Kara, Elif Demirci, Abdullah Uyanik   +6 more
doaj   +1 more source