Results 81 to 90 of about 26,882 (189)

The Experiences of Family Dyads During the Gender Identity Transition Process of Children and Adolescents

Scandinavian Journal of Caring Sciences, Volume 40, Issue 3, September 2026.
ABSTRACT Objective This study aims to analyse the transition process experienced by mother/father dyads when they recognise their children's gender dysphoria. Methodology The study employed a qualitative approach, based on interpretative description and the theoretical support of the transitions theory, in which 10 dyads participated.
Augusto Krindges, Guilherme da Silva Biasus, Carolina Andrade Costa, Tania Christiane Ferreira Bispo, Anderson Reis de Sousa, Jeferson Santos Araújo   +5 more
wiley   +1 more source

Characterization of the proneural gene regulatory network during mouse telencephalon development

BMC Biology, 2008
Background The proneural proteins Mash1 and Ngn2 are key cell autonomous regulators of neurogenesis in the mammalian central nervous system, yet little is known about the molecular pathways regulated by these transcription factors.
Parker Joel S, Nguyen Laurent, Castro Diogo S, Zimmer Celine, Smith Marjolein V, Parham Frederick M, Armant Olivier, Gohlke Julia M, Gradwohl Gerard, Portier Christopher J, Guillemot François   +10 more
doaj   +1 more source

SOX9 and TCF transcription factors associate to mediate Wnt/β-catenin target gene activation in colorectal cancer. [PDF]

J Biol Chem, 2023
Ramakrishnan AB, Burby PE, Adiga K, Cadigan KM.   +3 more
europepmc   +1 more source

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Central role of pericytes across major pulmonary diseases. Conceptual wheel diagram illustrating the central role of lung pericytes across diverse pulmonary disease states. A pericyte positioned at the center expresses canonical markers, including PDGFRβ, CD146, and NG2, and connects radially to five major disease contexts.
Stuti Agarwal, Anuradha Bankar, Vinicio A. de Jesus Perez   +2 more
wiley   +1 more source

The Mediator Med23 controls a transcriptional switch for muscle stem cell proliferation and differentiation in muscle regeneration

Cell Reports
Summary: Muscle stem cells (MuSCs) contribute to a robust muscle regeneration process after injury, which is highly orchestrated by the sequential expression of multiple key transcription factors. However, it remains unclear how key transcription factors
Yi Fang, Chunlei Yuan, Chonghui Li, Chengjiang Lu, Wei Yu, Gang Wang   +5 more
doaj   +1 more source

Protective Effects of Lactic Acid Bacteria Against TLR4 Induced Inflammatory Response in Hepatoma HepG2 Cells Through Modulation of Toll-Like Receptor Negative Regulators of Mitogen-Activated Protein Kinase and NF-κB Signaling

Frontiers in Immunology, 2018
The beneficial effects of probiotics in several liver diseases have been investigated in both animal and clinical models; however, the precise mechanisms responsible for their effects have not yet been elucidated.
Paulraj Kanmani, Hojun Kim
doaj   +1 more source

TCF/LEF family transcription factors: Molecular landscape and prognostic scoring in pan‐cancer

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
This study provides a comprehensive molecular landscape of TCF/LEF family transcription factors across 33 cancer types. We developed a TCF/LEF‐based prognostic score that correlates with immune infiltration, metabolic reprogramming and drug sensitivity, offering a robust transcriptomic signature for predicting patient survival and therapeutic response.
Zhengjun Yang, D. Q. Cai, Zhen Zhao, Zhixiang Jian, Mude Shi, Yajin Chen, Jueming Chen, Chunhua Qu, Diankui Cai   +8 more
wiley   +1 more source

SDCBP Cooperates With YBX1 to Promote ESCC Metastasis by Forming a Positive Feedback Loop With Wnt‐β‐Catenin Signaling Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
SDCBP interacted and cooperated with YBX1 to activate the Wnt/β‐catenin signaling pathway. Then, the activated Wnt/β‐catenin pathway targeted and induced the expression of SDCBP and other oncoproteins. The positive feedback loop between SDCBP and the Wnt/β‐catenin pathway accelerated the ESCC EMT process and promoted tumor metastasis. ABSTRACT Syndecan
Ruijuan Du, Bo Bian, Manyu Luo, Chen Yuan, Kelei Guo, Kai Li, Hui Zhang, Guangji Zhang, Li Han   +8 more
wiley   +1 more source

Baicalin Protects Mouse Testis From Injury Induced by PM2.5 Associated With the DKK1‐Wnt/β‐Catenin Signaling Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
ABSTRACT Fine particulate matter (PM2.5) has a damaging effect on the male reproductive system. Baicalin has excellent anti‐inflammatory and antioxidant pharmacological functions. The main purpose of this study was to investigate whether baicalin had a protective effect against PM2.5‐induced damage to the reproductive system of mice, and to further ...
Lili Deng, Juan Wang, Shuyin Li, Yaping Mao, Ye Sun, Qiaoqiao Yang, Zhenghui Xie, Chen Zhang, Shuo Gong, Chunling Xiao, Mingyue Ma   +10 more
wiley   +1 more source

TCF7L1 regulates colorectal cancer cell migration by repressing GAS1 expression

Scientific Reports
Dysregulated Wnt/β-catenin signaling is a common feature of colorectal cancer (CRC). The T-cell factor/lymphoid enhancer factor (TCF/LEF; hereafter, TCF) family of transcription factors are critical regulators of Wnt/β-catenin target gene expression.
Carli M. King, Wei Ding, Melanie A. Eshelman, Gregory S. Yochum   +3 more
doaj   +1 more source