Requirement of full TCR repertoire for regulatory T cells to maintain intestinal homeostasis [PDF]
, 2015 Junko Nishio +9 more
openalex +1 more source
Immune Exhaustion in Chronic Infection and Cancer: Signaling Pathways and Therapeutic Interventions
MedComm, Volume 7, Issue 3, March 2026.Immune exhaustion is a well‐established hallmark of both cancer and chronic infection. This review proposes a novel “infection–exhaustion–tumor axis” framework, wherein chronic pathogens (e.g., oncogenic viruses) evade immune surveillance by hijacking inflammatory signaling to drive immune cell exhaustion, thereby creating immunosuppressive niches ...
Yali Song +10 more
wiley +1 more source
Spatiotemporal commonality of the TCR repertoire in a T-cell memory murine model and in metastatic human colorectal cancer. [PDF]
Cancer Immunol Immunother, 2023 Haraguchi M +9 more
europepmc +1 more source
TCR repertoire in CD4 T cells of type 1 diabetes patients and healthy donors
, 2019 Iria Gómez-Touriño +4 more
openalex +1 more source
017 Single-cell T cell receptor (TCR) repertoire of skin and blood reveals skin-specific characteristics in health and HIV infection [PDF]
, 2022 Simona Saluzzo +5 more
openalex +1 more source
Evaluated and implemented SOPs. SOPs for TCR repertoire. Samples used for generating data to develop the tools and validate the software: melanoma, colorectal cancer, and ovarian cancer.
openaire +1 more source
Clinical Application of Peripheral Blood Biomarkers for Solid Tumors
MedComm, Volume 7, Issue 3, March 2026.Peripheral blood biomarkers provide a minimally invasive, dynamic, and potentially more accurate means to obtain a comprehensive tumor profile. Technologies for detecting them are advancing, and with the help of artificial intelligence, they are being used more and more often for cancer diagnosis, prognostic assessment, and therapeutic monitoring ...
Xinru Tu, Mengyan Tu, Junfen Xu
wiley +1 more source
Immune Tolerance Maintained by Cooperative Interactions between T Cells and Antigen Presenting Cells Shapes a Diverse TCR Repertoire [PDF]
, 2015 Katharine Best +2 more
openalex +1 more source
The Genomic Evolution of Early‐Stage Non‐Small Cell Lung Cancer
Medicine Advances, Volume 4, Issue 1, Page 1-9, March 2026.This study provides a comprehensive overview of the genomic landscape of early‐stage non‐small cell lung cancer, identifying the 4q12 deletion as a potential exclusive biomarker for the “oncogenic switch” from pre‐invasive to invasive lesions. It delineates that while EGFR and TP53 mutations act as early truncal drivers, the progressive increase in ...
Huatao Tang, Yang Zhang, Haiquan Chen
wiley +1 more source
MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source