Results 251 to 260 of about 58,781 (291)

Deep learning-driven TCR$$\beta$$ repertoire analysis enhances diagnosis and enables mining of immunological biomarkers in systemic lupus erythematosus [PDF]

Tongfei Shen, Yifei Sheng, Wan Nie, Shuo Yang, K.K. Li, Ziwei Ma, Zhao Ling, Bowen Tan, Xikang Feng, Miaozhe Huo   +9 more
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Stable global repertoire architecture masks short-term clonal remodeling in intratumoral TCR repertoires [PDF]

P K. Pedersen, Odd L. Gammelgaard, Sofie Traynor, Christina H. Ruhlmann, Aida S. Hansen, Henrik J. Ditzel, Morten F. Gjerstorff, Mikkel G. Terp   +7 more
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Single-Cell Dissection of Prognostic Determinants in PDAC based on Single-Cell Transcriptomics and TCR Repertoire Analysis

Zhiwei Li
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Data Sheet 1_Peripheral blood TCR repertoire improves early detection across multiple cancer types utilizing a cancer predictor.docx

Yinglei Tang (22130068), Xinyi Liao (10889523), Bo Liao (287406), Dejun Peng (13409744), Qingbo Li (2203015)   +4 more
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TCR sequencing and cloning methods for repertoire analysis and isolation of tumor-reactive TCRs [PDF]

Cell Reports Methods, 2023
T cell receptor (TCR) technologies, including repertoire analyses and T cell engineering, are increasingly important in the clinical management of cellular immunity in cancer, transplantation, and other immune diseases. However, sensitive and reliable methods for repertoire analyses and TCR cloning are still lacking.
Alexandra Michel, Patrick Reichenbach, Julien Schmidt   +2 more
exaly   +3 more sources

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TCR-beta repertoire development in the mouse embryo

The Journal of Immunology, 1997
Abstract We studied the TCR beta-chain repertoire in thymocytes along embryonic development. At day 14 of gestation, complete V-D-J rearrangements of the TCR-beta locus were detected at the messenger RNA level, and a total of 56 different rearrangements were observed in one thymus.
H, Ema, A, Cumano, P, Kourilsky
openaire   +2 more sources

TCR repertoire in early fetal mouse thymus

International Immunology, 1995
We investigated the rearrangement and expression of TCR genes in mouse fetal thymus organ culture, a system that avoids subsequent entry of hematopoietic precursor cells. The first observable rearranged TCR gene was homogeneous V gamma 2-J gamma 2, detectable as early as fetal day 11 (d11) in the thymic primordia.
H, Ohki-Hamazaki, Y, Makino, M, Kanno, H, Koseki, T, Akasaka, M, Taniguchi   +5 more
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Individuality of Ag-Selected and Preimmune TCR Repertoires

Immunologic Research, 2001
We have combined flow cytometry and single-cell PCR to characterize the TCRBV repertoires selected by individual mice in a model CD8 response against a defined peptide/MHC complex (CW3 170-1 79/Kd). Ourresults established thatdifferent mice select individually distinct yet structurally similar CW3-specific repertoires.
J L, Maryanski, V, Attuil, A, Hamrouni, M, Mutin, M, Rossi, A, Aublin, P, Bucher   +6 more
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Characterizing the TCR repertoire in Neuropsychiatric Lupus

The Journal of Immunology, 2020
Abstract Approximately 40% of lupus patients experience neurological and/or psychiatric disorders. However, the mechanisms contributing to the wide range of neuropsychiatric manifestations (NPSLE) have not yet been fully elucidated.
Erica Moore, Michelle Huang, Chaim Putterman   +2 more
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Chronic Modulation of the TCR Repertoire in the Lymphoid Periphery

The Journal of Immunology, 1999
Abstract Using TCR Vβ5 transgenic mice as a model system, we demonstrate that the induction of peripheral tolerance can mold the TCR repertoire throughout adult life. In these mice, three distinct populations of peripheral T cells are affected by chronic selective events in the lymphoid periphery.
C A, Blish, B J, Gallay, G L, Turk, K M, Kline, W, Wheat, P J, Fink   +5 more
openaire   +2 more sources